The Talpur Baloch soon gained power and overthrew the Kalhora after the Battle of Halani. Peace between the two warring tribes was soon established and in the year 1783, His Highness Mir Fateh Ali Khan Talpur as the new Amir of Sindh. This brought an end to the ferocious fighting and the defeat of the ruling Kalhora by the Talpur tribes.
In the middle of the XVIII century. in the Sindehili were feudal lords of Balochi tribe of the Talpurs, who were in vassalage from the Kalhoras. Taking advantage of the fact that the population was extremely is outraged by the tyranny of the Nawab (ruler) Abdullah Nabi Kalhor, the leaders of the Talpurs raised in June 1779 an uprising and ousted Abdullah Nabis, seized power. Nawab fled to Kandahar, hoping to find support with his suzerain Timur Shah.
Timur Shah agreed to help him, and in 1781 Abdullah Nabi with the assistance of The Afghan troops again became the ruler of Sind. However, fermentation in the country not only did not stop but broke out with renewed vigor. Relying on the support of the disaffected nawab population, the leader of the Talpurs Fatah Ali Khan expelled Abdullah Nabi from Sind in 1783. Sent Timur Shah to the aid of the rulers of Kalhor, a detachment of Afghan troops was defeated by the Balochs in 1786 near Shikarpur.
|Tenure||Amirs of Khairpur|
|1775–1811||Amir Sohrab Khan Talpur|
|1811 - 20 December 1842||Amir Rustam Ali Khan Talpur|
|1829–1839||Amir Mubarak Ali Khan Talpur (challenger)|
|1839–1842||Amir Nasir Khan Talpur (challenger)|
|20 December 1842 - 2 April 1894||Amir Ali Murad Khan Talpur|
|2 April 1894 – 6 March 1909||Amir Faiz Mohammad Khan Talpur I|
|6 March 1909 – 8 February 1921||Amir Imam Bakhsh Khan Talpur|
|8 February 1921 – 25 June 1921||Interregnum|
|25 June 1921 – 25 December 1935||Amir Ali Nawaz Khan Talpur|
|25 December 1935 – 19 July 1947||Amir Faiz Mohammad Khan Talpur II|
|19 July 1947 – 14 October 1955||Ayaz Talpur|
|14 October 1955||Monarchy abolished|