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Year 1515 (MDXV) was a common year starting on Monday (link will display the full calendar) of the Julian calendar.
- July 2 – Manchester Grammar School is endowed by Hugh Oldham, the first free grammar school in England.
- July 22 – At the First Congress of Vienna, a double wedding takes place to cement agreements. Louis, only son of King Vladislaus II of Hungary, marries Mary of Austria, granddaughter of Maximilian I, Holy Roman Emperor; and Mary's brother, Archduke Ferdinand, marries Vladislaus' daughter, Anna.
- August 25 – Conquistador Diego Velázquez de Cuéllar founds Havana, Cuba.
- September 13–14 – Battle of Marignano: The army of Francis I of France defeats the Swiss, thanks to the timely arrival of a Venetian army. Francis restores French control of Milan.
- November 15 – Thomas Wolsey is invested as a Cardinal.
- December 24 – Thomas Wolsey is named Lord Chancellor of England.
- January 1 – Johann Weyer, Dutch physician (d. 1588)
- February 4 – Mikołaj "the Black" Radziwiłł, Polish magnate (d. 1565)
- February 14 – Frederick III, Elector Palatine, ruler from the house of Wittelsbach (d. 1576)
- February 18 – Valerius Cordus, German physician, botanist and author (d. 1544)
- March 10 – Injong of Joseon, 12th king of the Joseon Dynasty of Korea (d. 1545)
- March 12 – Caspar Othmayr, German Protestant priest, theologian and composer (d. 1553)
- March 28 – Teresa of Ávila, Spanish Carmelite nun, poet and saint (d. 1582)
- May 2 – Sibylle of Saxony, Duchess of Saxe-Lauenburg (d. 1592)
- May 12
- June 15 – Anne Parr, Countess of Pembroke, English countess (d. 1552)
- July 4 – Eleonora d'Este (d. 1575)
- July 10 – Francisco de Toledo, Viceroy of Peru (d. 1582)
- July 14 – Philip I, Duke of Pomerania-Wolgast (d. 1560)
- July 21 – Philip Neri, Italian Roman Catholic saint (d. 1595)
- September 8 – Alfonso Salmeron, Spanish biblical scholar and early Jesuit (d. 1585)
- September 22 – Anne of Cleves, Fourth Queen of Henry VIII of England (d. 1557)
- October 4 – Lucas Cranach the Younger, German painter (d. 1586)
- October 7 – Infante Duarte, Duke of Guimarães, son of King Manuel I of Portugal (d. 1540)
- October 8 – Margaret Douglas, daughter of Archibald Douglas (d. 1578)
- October 15 – Leone Strozzi, French Navy admiral (d. 1554)
- October 29
- November 22 – Mary of Guise, queen of James V of Scotland and regent of Scotland (d. 1560)
- December 15 – Maria of Saxony, Duchess of Pomerania (d. 1583)
- date unknown
- January 1 – King Louis XII of France (b. 1462)
- February 6 – Aldus Manutius, Venetian printer (b. c. 1449)
- March 16 – Queen Janggyeong, Korean royal consort (b. 1491)
- April 15 – Mikołaj Kamieniecki, Polish nobleman (szlachcic) and first Great Hetman of the Crown (b. 1460)
- September 4 – Barbara of Brandenburg, Bohemian queen (b. 1464)
- September 9 – Joseph Volotsky, caesaropapist ideologist of the Russian Orthodox Church
- October – Bartolomeo d'Alviano, Venetian general (b. 1455)
- November 5 – Mariotto Albertinelli, Italian painter (b. 1474)
- December 2 – Gonzalo Fernández de Córdoba, Spanish general and statesman (b. 1453)
- December 16 – Afonso de Albuquerque, Portuguese naval general (b. 1453)
- December 18 – Alexander Stewart, Duke of Ross, Scottish prince (b. 1514)
- date unknown
- probable – Vincenzo Foppa, Italian Renaissance painter (b. 1430)
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