The FASEB Journal is a scientific journal related to experimental biosciences, promoting scientific progress and education. It is published by the Federation of American Societies for Experimental Biology, that was founded in 1912 originally by 3 societies (29 as of January 2019, see current list).
|The FASEB Journal|
|Edited by||Thoru Pederson, PhD|
3-Iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein-coupled receptor. T1AM is the most potent endogenous TAAR1 agonist yet discovered. Activation of TAAR1 by T1AM results in the production of large amounts of cAMP. This effect is coupled with decreased body temperature and cardiac output. Wu et al. have pointed out that this relationship is not typical of the endocrine system, indicating that TAAR1 activity may not be coupled to G-proteins in some tissues, or that T1AM may interact with other receptor subtypes.T1AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.Avimer
Avimers (short for avidity multimers) are artificial proteins that are able to specifically bind to certain antigens via multiple binding sites. Since they are not structurally related to antibodies, they are classified as a type of antibody mimetic. Avimers have been developed by the biotechnology company Avidia, now part of Amgen, as potential new pharmaceutical drugs.Dipeptidase 2
Dipeptidase 2 (DPEP2) is a protein which in humans is encoded by the DPEP2 gene.DPEP2 belongs to the membrane-bound dipeptidase (EC 126.96.36.199) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation.Dipeptidase 3
Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.This gene encodes a membrane-bound glycoprotein from the family of dipeptidases (EC 188.8.131.52) involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family, DPEP2. Alternatively spliced transcript variants that encode different isoforms have been found for this gene.Dyad pedagogy
Dyad pedagogy is a goal-directed teaching method. Students are randomly assigned into dyads and work together on inquiry-type problems. The educational method was developed by Dr. Lloyd Sherman, a professor at the Mount Sinai School of Medicine in New York City during the 1990s.Extensor indicis muscle
In human anatomy, the extensor indicis [proprius] is a narrow, elongated skeletal muscle in the deep layer of the dorsal forearm, placed medial to, and parallel with, the extensor pollicis longus. Its tendon goes to the index finger, which it extends.Federation of American Societies for Experimental Biology
The Federation of American Societies for Experimental Biology, abbreviated FASEB, is a non-profit organization that is the principal umbrella organization of U.S. societies in the field of biological and medical research. FASEB organizes academic conferences and publishes scientific literature.Free fatty acid receptor
The free fatty acid receptor is a G-protein coupled receptor which binds free fatty acids. There are four variants of the receptor, each encoded by a separate gene (FFAR1, FFAR2, FFAR3, FFAR4). Preliminary findings suggest that FFAR2 and FFAR3 may interact to form a FFAR2-FFAR3 receptor heteromer.GAL-021
GAL-021 is a drug related to almitrine which acts as a respiratory stimulant, with its mechanism of action primarily thought to involve blocking the BKCa potassium channel, although secondary mechanisms may also be involved. It was developed by Galleon Pharmaceuticals, and is being tested in clinical trials for potential uses in post-operative care, as well as more generally to counteract the respiratory depression which can be a side effect of opioid analgesic drugs.Gerald Weissmann
Gerald Weissmann is an American physician/scientist, editor and essayist. He is Professor Emeritus and Research Professor of Medicine (Rheumatology) at New York University School of Medicine. He was Editor-in-Chief (2006–16) of The FASEB Journal. He is now its Book Review editor.Langerin
CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene. Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.List of biology journals
This is a list of articles about scientific journals in biology and its various subfields.Luzindole
Luzindole (N-0774), (N-acetyl-2-benzyltryptamine), is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as a selective melatonin receptor antagonist, with approximately 11- to 25-fold greater affinity for the MT2 over the MT1 receptor. In animal studies, it has been observed to disrupt the circadian rhythm as well as produce antidepressant effects.Lysophosphatidylinositol
Lysophosphatidylinositol (LPI, lysoPI), or L-α-lysophosphatidylinositol, is an endogenous lysophospholipid and endocannabinoid neurotransmitter. LPI, along with its 2-arachidonoyl- derivative, 2-arachidonoyl lysophosphatidylinositol (2-ALPI), have been proposed as the endogenous ligands of GPR55.SCImago Journal Rank
SCImago Journal Rank (SJR indicator) is a measure of scientific influence of scholarly journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from. A journal's SJR is a numeric value indicating the average number of weighted citations received during a selected year per document published in that journal during the previous three years. Higher SJR values are meant to indicate greater journal prestige.
The SJR indicator is a variant of the eigenvector centrality measure used in network theory. Such measures establish the importance of a node in a network based on the principle that connections to high-scoring nodes contribute more to the score of the node. The SJR indicator has been developed to be used in extremely large and heterogeneous journal citation networks. It is a size-independent indicator and its values order journals by their "average prestige per article" and can be used for journal comparisons in science evaluation processes. The SJR indicator is a free journal metric inspired by, and using an algorithm similar to, PageRank.
The SJR indicator provides an alternative to the impact factor (IF) or average citations per document in a 2-year period, abbreviated as "Cites per Doc. (2y)".Serial dilution
A serial dilution is the stepwise dilution of a substance in solution. Usually the dilution factor at each step is constant, resulting in a geometric progression of the concentration in a logarithmic fashion. A ten-fold serial dilution could be 1 M, 0.1 M, 0.01 M, 0.001 M ... Serial dilutions are used to accurately create highly diluted solutions as well as solutions for experiments resulting in concentration curves with a logarithmic scale. A tenfold dilution for each step is called a logarithmic dilution or log-dilution, a 3.16-fold (100.5-fold) dilution is called a half-logarithmic dilution or half-log dilution, and a 1.78-fold (100.25-fold) dilution is called a quarter-logarithmic dilution or quarter-log dilution. Serial dilutions are widely used in experimental sciences, including biochemistry, pharmacology, microbiology, and physics.Steven Zeisel
Steven H. Zeisel is a Kenan Distinguished University Professor in Nutrition and Pediatrics; former Chairman, Department of Nutrition; Director Nutrition Research Institute, Director UNC Human Clinical Nutrition Research Center, Director UNC Center for Excellence in Children’s Nutrition, School of Public Health, University of North Carolina at Chapel Hill.Thromboregulation
Thromboregulation is the series of mechanisms in how a primary clot is regulated. These mechanisms include, competitive inhibition or negative feedback. It includes primary hemostasis, which is the process of how blood platelets adhere to the endothelium of an injured blood vessel. Platelet aggregation is fundamental to repair vascular damage and the initiation of the blood thrombus formation. The elimination of clots is also part of thromboregulation. Failure in platelet clot regulation may cause hemorrhage or thrombosis. Substances called thromboregulators control every part of these events.