ISO 5 is an international standard for density measurements in photography and graphic technology. The most recent version split the standard into 4 parts:[1]

  • ISO 5-1:2009 Geometry and functional notation
  • ISO 5-2:2009 Geometric conditions for transmittance density
  • ISO 5-3:2009 Spectral conditions
  • ISO 5-4:2009 Geometric conditions for reflection density


  1. ^ "ISO 5-1:2009 - Photography and graphic technology -- Density measurements -- Part 1: Geometry and functional notation".
Alfred Young Nutt

Alfred Young Nutt, MVO, ISO (5 May 1847 – 25 July 1924) was an English architect and artist, who was Surveyor to the Dean and Canons of St George's Chapel, Windsor in the late 19th century.


Argotec is an aerospace engineering company based in Turin whose research, innovation and product development activities use engineering and computing for space applications and renewable energy systems. Particular attention is also given to the field of Human Space Flight and Operations as well as the development of space exploration systems. Argotec is also concerned with the production of nanosatellites and engineering solutions that can be adopted on the International Space Station (ISS), which also have immediate applications on Earth.

Atsuhime (TV series)

Atsuhime (篤姫, "Princess Atsu") is a 2008 Japanese television series. It is the 47th NHK Taiga drama. It debuted on January 6, 2008, and aired throughout 2008, completing its run of 50 episodes on December 14, 2008. The story chronicles the life of Tenshōin, based on Tomiko Miyao's 1984 novel Tenshō-in Atsuhime (天璋院篤姫).

Barrier isolator

Barrier isolator is a general term that includes two types of devices: isolators and restricted access barriers (RABS). Both are devices that provide a physical and aerodynamic (air overpressure) barrier between the external clean room environment and a work process. The isolator design is the more dependable of the two barrier design choices, as it prevents contamination hazards by achieving a more comprehensive separation of the processing environment from the surrounding facility. Nonetheless, both Isolator and RABS designs are contemporary approaches developed over the last 35 years and a great advancement over designs of the 1950s-70s that were far more prone to microbial contamination problems.

Barrier and Isolator designs are used throughout the industries, from sterile injectable drug filling to cytotoxic sterile drug compounding to electronics manufacturing to orange juice filling. Pharmaceutical industry and pharmacy compounding isolators are used for maintaining sterility of a drug, and that is the focus of this article. This type of strict design and control is important when producing sterile medicines because consumers receiving injections, surgical irrigants, or other "parenterally"-administered drugs are often highly vulnerable to infection. As a result, contaminated drugs have caused grave (e.g., permanent injury, death) consequences for the consumer. The sterility of other dosage forms, such as ophthalmics, is similarly important, as blindness or partial loss of vision has occurred due to intrinsically contaminated eye medications.

Isolators are routinely found within the pharmaceutical industry and are widely used in Europe (and increasingly in the US) for pharmacy aseptic compounding applications. See also Asepsis. They are designed to provide continuous and complete isolation of the inside of the isolator from the external room environment (including its operators). Only installed gloves or robotic arms are used to manipulate the product. This ensures that the environment is maintained as contamination-free to safeguard patients who will later be administered the drug. Isolators operate as positive-pressure devices, and use full wall separation and substantial overpressure to both physically and aerodynamically separate the interior from the external room environment. The more complete technical definition is as follows:

An isolator is a decontaminated unit, supplied with Class 100 (ISO 5) or higher air quality, that provides uncompromised, continuous isolation of its interior from the external environment (e.g., surrounding cleanroom air and personnel). There are two major types of isolators:

Closed Isolator operation "Closed isolator" systems exclude external contamination from the isolator's interior by accomplishing material transfer via aseptic connection to auxiliary equipment, rather than use of openings to the surrounding environment. Closed systems remain sealed throughout operations.

Open Isolator "Open Isolator" systems are designed to allow for the continuous or semi-continuous ingress and/or egress of materials during operations through one or more openings. Openings are engineered (i.e., using continuous overpressure) to exclude external contamination from entering the isolator chamber.While the positive pressure isolator is most common, "negative" pressure devices also exist for very large industrial operations that handle toxic products. The "negative pressure isolator," and has become less common and desirable, but is superior to the traditional biosafety cabinet which is vulnerable to contamination and can expose the worker to toxicological hazards if not operated properly.

A simpler and more effective option for nearly all toxicological containment applications is the use of "closed isolator" design, which is maintained under positive pressure (this is the most appropriate containment option unless a company processes thousands of units per minute).

If a negative isolator is used, its intricate design must fulfill two objectives: protect workers outside of the isolator, and assure sterility of sterile drugs inside the isolator. As such, the term "negative pressure" isolator is somewhat of a misnomer, as contaminated ("polluted") room air must not be pulled into the main workstation isolator in a sterile operation. Thus, the actual workstation isolator is always maintained under substantial positive pressure. The "negative" pressure isolator does however include a separate buffer zone (an extra isolator compartment) that is designed to exhaust both incoming room air and outgoing positive pressure air from the main workstation. The main workstation isolator, in which the sterile product is exposed, is therefore protected from contaminated air as the toxic product should be exhausted via the buffer zone before it reaches operators working outside of the isolation.

In addition to Isolators, there are also extensive barriers that provide sub-isolation protection, but have a very good track record of reducing hazards to sterile drugs during processing when they are designed and operated properly. This extensive barrier is known as a restricted access barrier system, or RABS. A barrier cabinet using RABS design and control, is below the isolator in its ability to assure sterility assurance and containment, but far better than the traditional laminar air flow hood or "open process" designs that are progressively being phased-out by the industries. In particular, a RABS that operates only in closed-door mode after the equipment setup and sporadical disinfection is performed, is commonly used now and provides substantial risk mitigation. These "closed RABS" require all processing interventions to be done using gauntlet gloves attached to the RABS walls. RABS doors are only opened at the start of an operation to perform equipment setup, and must be locked thereafter until the conclusion of operations.

In contrast, other RABS designs allow for rare door openings in specified circumstances. Because this "open RABS" allows for a door to be opened to the surrounding cleanroom (albeit into a fully HEPA-filtered perimeter around the RABS structure) during aseptic operations, the design allows for higher contamination hazard than a RABS that is kept closed. If doors are opened to the "open RABS" on anything other than an exceptional basis, it may not represents an improvement over traditional aseptic processes. Therefore, "open RABS" must be operated properly to realize sterility assurance gains.

Some historical background regarding isolators and RABS is also important to understand how sterile product proaction has evolved. In the mid-1980s, after the industry had already begun to employ isolators, RABS units became an alternative to separating people from the process. While isolator usage continued to expand, RABS also became popular in the 1990s. The acronym RABS was coined by Stewart Davenport of Upjohn (now Pfizer). (See ISPE publications for a definition of RABS.) Since that time, the technology and applications of these systems has developed and broadened significantly. It is now very unusual for a sterile drug operation to be run without either an Isolator or RABS protective design.

There are also other devices, which can offer some helpful separation. These devices are known as Gloveboxes. Gloveboxes do not offer the separative control provisions of an isolator or RABS. Gloveboxes were originally designed for non-sterile product applications, such as weighing or manipulating a toxic drug and have a long track record for such non-sterile applications. Such gloveboxes can be very effective in preventing exposure of an operator to a toxic drug. In limited cases, they can also be used to protect a sterile product, when supplied with ISO 5 unidirectional air. However, in some notable cases, gloveboxes used for aseptic processing have provided no more sterile product protection than the traditional laminar air flow hood (LAF) design of the 1960s. In these cases, the glove boxes were problematic due to inappropriate design or controls (e.g., insufficient disinfection, transfer of contaminated materials, ingress of lower quality air into glovebox, poor design/integrity, poor transfers). However, if gloveboxes are very meticulously designed, thoroughly disinfected (e.g., using a sporadical) and carefully operated by well-trained aseptic processing personnel to prevent introduction of microbial contamination, it is possible to obtain some degree of increased sterile product protection versus the simple traditional LAF hood.

Binnig and Rohrer Nanotechnology Center

Binnig and Rohrer Nanotechnology Center in Rüschlikon/ZH is a Research Facility for Nanotechnology owned by IBM.

This building was named after the two Nanotech-Pioneers and Nobelaureates Gerd Binnig and Heinrich Rohrer, who invented the Scanning Tunneling Microscope in the year 1986 in the Zurich Research Laboratory next to the Nanotechnology Center.

The Binnig and Rohrer Nanotechnology Center is specialized on basic research but also in photonics and nanotechnology. The facility is based on the premise of open collaboration with IBM scientists and external partners. One of these partners is ETH Zurich, the renowned Swiss university that agreed to rent part of the Center for 10 years. EMPA is a third partner.


A cleanroom or clean room is a facility ordinarily utilized as a part of specialized industrial production or scientific research, including the manufacture of pharmaceutical items and microprocessors. Cleanrooms are designed to maintain extremely low levels of particulates, such as dust, airborne organisms, or vaporized particles. Cleanrooms typically have an cleanliness level quantified by the number of particles per cubic meter at a predetermined molecule measure. The ambient outdoor air in a typical urban area contains 35,000,000 particles for each cubic meter in the size range 0.5 μm and bigger in measurement, equivalent to an ISO 9 cleanroom, while by comparison an ISO 1 cleanroom permits no particles in that size range and just 12 particles for each cubic meter of 0.3 μm and smaller.

Compact Disc manufacturing

Compact disc manufacturing is the process by which commercial compact discs (CDs) are replicated in mass quantities using a master version created from a source recording. This may be either in audio form (CD-Audio) or data form (CD-ROM). This process is used in the mastering of read-only compact discs; CD-Rs, CD-RWs, and DVDs are made somewhat differently, though the methods are broadly similar.

A CD can be used to store audio, video, and data in various standardized formats defined in the Rainbow Books. CDs are usually manufactured in a class 100 (ISO 5) or better clean room; they can usually be manufactured to quite strict manufacturing tolerances for only a few US cents per disk.

CD mastering differs from burning, as the pits and lands of a mastered CD are moulded into a CD blank, rather than being 'burn marks' in a dye layer (in CD-Rs) or areas with changed physical characteristics (in CD-RWs). In addition, CD burners write data sequentially, while a CD pressing plant 'writes' the entire disk in one physical stamping operation.

Harold Turbott

Harold Bertram Turbott (5 August 1899 – 16 March 1988) was a notable New Zealand doctor, public health administrator, broadcaster and writer. He was born in Auckland, New Zealand, in 1899.In the 1959 Queen's Birthday Honours, Turbott was appointed a Companion of the Imperial Service Order.

List of International Organization for Standardization standards, 1-4999

This is a list of published International Organization for Standardization (ISO) standards and other deliverables. For a complete and up-to-date list of all the ISO standards, see the ISO catalogue.The standards are protected by copyright and most of them must be purchased. However, about 300 of the standards produced by ISO and IEC's Joint Technical Committee 1 (JTC1) have been made freely and publicly available.

Particle counter

A particle counter is an instrument that detects and counts physical particles.

Paul Keaney

Brother Paul Francis Keaney, MBE, ISO (5 October 1888 - 26 February 1954) was an accused paedophile and Irish-born Australian Catholic educator.

ISO standards by standard number

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