GNAI1

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.[5][6]

GNAI1
Protein GNAI1 PDB 1agr
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGNAI1, Gi, G protein subunit alpha i1
External IDsMGI: 95771 HomoloGene: 74417 GeneCards: GNAI1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002069
NM_001256414

NM_010305

RefSeq (protein)

NP_001243343
NP_002060

NP_034435

Location (UCSC)Chr 7: 79.77 – 80.23 MbChr 5: 18.27 – 18.36 Mb
PubMed search[3][4]
Wikidata

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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Nicotine Activity on Dopaminergic Neurons edit
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  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

GNAI1 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127955 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057614 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5115–9. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783.
  6. ^ "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".
  7. ^ Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nature Genetics. 23 (1): 108–12. doi:10.1038/12715. PMID 10471510.
  8. ^ a b Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
  9. ^ Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (Apr 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. doi:10.1038/416878a. PMID 11976690.
  10. ^ Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
  11. ^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
  12. ^ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
  13. ^ Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

Further reading

PDB 1agr EBI

1agr: COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4

PDB 1as0 EBI

1as0: GTP-GAMMA-S BOUND G42V GIA1

PDB 1as2 EBI

1as2: GDP+PI BOUND G42V GIA1

PDB 1as3 EBI

1as3: GDP BOUND G42V GIA1

PDB 1bh2 EBI

1bh2: A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT

PDB 1bof EBI

1bof: GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM

PDB 1cip EBI

1cip: GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE

PDB 1gdd EBI

1gdd: TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS

PDB 1gfi EBI

1gfi: STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS

PDB 1gg2 EBI

1gg2: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND

PDB 1gia EBI

1gia: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS

PDB 1gil EBI

1gil: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS

PDB 1git EBI

1git: STRUCTURE OF GTP-BINDING PROTEIN

PDB 1gp2 EBI

1gp2: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND

PDB 1kjy EBI

1kjy: Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14

PDB 1svk EBI

1svk: Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP

PDB 1svs EBI

1svs: Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.

PDB 1y3a EBI

1y3a: Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

PDB 2g83 EBI

2g83: Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit

PDB 2gtp EBI

2gtp: Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1

PDB 2hlb EBI

2hlb: A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity

PDB 2ihb EBI

2ihb: Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3

PDB 2ik8 EBI

2ik8: Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1

PDB 2ode EBI

2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

GPR143

G-protein coupled receptor 143 is a protein encoded by the GPR143 gene in humans.Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes.The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.L-DOPA is an endogenous ligand for OA1.

Gi alpha subunit

Gi (Gαi, or Gi/Go or Gi/o or Gi protein) alpha subunit is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP. A mnemonic for remembering this subunit is to look at first letter (Gαi = Adenylyl Cyclase inhibitor).

Heterotrimeric G protein

"G protein" usually refers to the membrane-associated heterotrimeric G proteins, sometimes referred to as the "large" G proteins (as opposed to the subclass of smaller, monomeric small GTPases) . These proteins are activated by G protein-coupled receptors and are made up of alpha (α), beta (β) and gamma (γ) subunits, the latter two referred to as the beta-gamma complex.

There are four main families of G proteins: Gi/Go, Gq, Gs, and G12.

RGS12

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.

RGS14

Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.

RGS19

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.

RGS20

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]In melanocytic cells RGS20 gene expression may be regulated by MITF.

RIC8A

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.

S1PR1

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.

List of PDB id codes

1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8

Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GNAI1
Genomic location for GNAI1
Band7q21.11Start79,768,028 bp[1]
End80,226,181 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for GNAI1
Genomic location for GNAI1
Band5 A3|5 8.16 cMStart18,265,135 bp[2]
End18,360,355 bp[2]
RNA expression pattern
PBB GE GNAI1 209576 at fs
More reference expression data
Gene ontology
Molecular function GTPase activating protein binding
nucleotide binding
G-protein beta/gamma-subunit complex binding
GDP binding
G-protein coupled serotonin receptor binding
signal transducer activity
metal ion binding
protein binding
guanyl nucleotide binding
G-protein coupled receptor binding
GTP binding
magnesium ion binding
GTPase activity
Cellular component cytoplasm
centrosome
membrane
plasma membrane
intracellular
protein complex
microtubule organizing center
lysosomal membrane
midbody
heterotrimeric G-protein complex
membrane raft
extracellular exosome
cytoskeleton
cell nucleus
nucleolus
cell cortex region
cell cortex
Biological process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
response to peptide hormone
negative regulation of synaptic transmission
cell division
cell cycle
signal transduction
regulation of cAMP-mediated signaling
cellular response to forskolin
protein folding
regulation of mitotic spindle organization
positive regulation of protein localization to cell cortex
transport
G-protein coupled receptor signaling pathway
Sources:Amigo / QuickGO
MAP
Calcium
G protein
Cyclin
Lipid
Other protein kinase
Other protein phosphatase
Apoptosis
GTP-binding protein regulators
Other
3.6.1
3.6.2
3.6.3-4: ATPase
3.6.5: GTPase

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