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1agr: COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4
1as0: GTP-GAMMA-S BOUND G42V GIA1
1as2: GDP+PI BOUND G42V GIA1
1as3: GDP BOUND G42V GIA1
1bh2: A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT
1bof: GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
1cip: GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE
1gdd: TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS
1gfi: STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS
1gg2: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
1gia: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
1gil: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
1git: STRUCTURE OF GTP-BINDING PROTEIN
1gp2: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND
1kjy: Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14
1svk: Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP
1svs: Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.
1y3a: Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
2g83: Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit
2gtp: Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1
2hlb: A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity
2ihb: Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3
2ik8: Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1
2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3
G-protein coupled receptor 143 is a protein encoded by the GPR143 gene in humans.Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes.The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.L-DOPA is an endogenous ligand for OA1.
Gi (Gαi, or Gi/Go or Gi/o or Gi protein) alpha subunit is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP. A mnemonic for remembering this subunit is to look at first letter (Gαi = Adenylyl Cyclase inhibitor).
"G protein" usually refers to the membrane-associated heterotrimeric G proteins, sometimes referred to as the "large" G proteins (as opposed to the subclass of smaller, monomeric small GTPases) . These proteins are activated by G protein-coupled receptors and are made up of alpha (α), beta (β) and gamma (γ) subunits, the latter two referred to as the beta-gamma complex.
There are four main families of G proteins: Gi/Go, Gq, Gs, and G12.
Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.
Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.
Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]In melanocytic cells RGS20 gene expression may be regulated by MITF.
Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.
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