Derek Lowe

Derek Christopher Lowe (born June 1, 1973) is a former Major League Baseball pitcher. During his career, he played for the Seattle Mariners, Boston Red Sox, Los Angeles Dodgers, Atlanta Braves, Cleveland Indians, New York Yankees, and Texas Rangers.

Lowe threw a no-hitter for the Red Sox in 2002. In the 2004 post-season he had a 3–0 win–loss record as he helped lead Boston to its first World Series championship in 86 years.

Derek Lowe
Derek Lowe Atlanta Braves
Lowe with the Atlanta Braves in 2009
Born: June 1, 1973 (age 46)
Dearborn, Michigan
Batted: Right Threw: Right
MLB debut
April 26, 1997, for the Seattle Mariners
Last MLB appearance
May 19, 2013, for the Texas Rangers
MLB statistics
Win–loss record176–157
Earned run average4.03
Career highlights and awards

Early years

Lowe attended Edsel Ford High School in Dearborn, Michigan, where he was a four-sport letterman in baseball, golf, soccer, and basketball. He was an All-League honoree in all four sports, and was a first-team all-state pick in basketball. Lowe committed to attend Eastern Michigan University on a basketball scholarship.[1]

Baseball career

Minor leagues

The Seattle Mariners drafted Lowe in the eighth round of the 1991 MLB draft. He signed with the Mariners on June 7, 1991, forgoing his college scholarship.[1] The Mariners immediately assigned him to their rookie league team, where he went 5–3 with a 2.41 earned run average (ERA) in 12 starts.

He spent the next several years working his way through several minor league teams: 1992 – Single-A Bellingham (7–3, 2.42 – 13 starts), 1993 – Single-A Riverside (12–9, 5.26, 26 starts), 1994 – Double-A Jacksonville (7–10, 4.94, 26 starts), 1995 – Double-A Port City (1–6, 6.08, 10 starts), 1996 – Triple-A Tacoma (6–9, 4.54, 16 starts).

Seattle Mariners

Lowe made his major league debut on April 26, 1997, working 3​23 innings in relief against the Toronto Blue Jays. He made his first major league start on May 27, 1997, against the Minnesota Twins, giving up four runs in 5 innings. His first career win came on June 6 against the Detroit Tigers, pitching 5​13 innings and giving up 3 runs in the Mariners 6–3 victory.

Seattle, however, was desperate for immediate bullpen help and packaged Lowe and catcher Jason Varitek into a deal with the Boston Red Sox for Heathcliff Slocumb.[1][2] The trade is considered one of the most lopsided in MLB history.

Derek Lowe and Pedro Martinez WS Victory Parade
Derek Lowe (left) and Pedro Martínez at the Red Sox World Series Victory Parade in 2004.

Boston Red Sox

Lowe compiled a 5–15 record over his first two seasons, during which he split time starting and relieving, but came into his own in 1999 after being transferred into the closer's role, finishing the season with 15 saves and a 2.63 ERA.[1]

Lowe had his best season as a closer in 2000 when he led the American League with 42 saves and recorded a 2.56 ERA.[1] Despite recording 24 saves early in the 2001 season, Lowe lost the closer's job soon after the trading deadline when the Red Sox acquired Ugueth Urbina.[1] Lowe was left in limbo, forced to take various setup jobs in the bullpen. Lowe asked manager Joe Kerrigan to return him to the starting rotation, and he pitched 16 innings as a starter before the end of the season.[1] As a starter in 2002, Lowe posted a 21–8 record, a 2.58 ERA, and finished third in Cy Young Award voting behind Barry Zito and teammate Pedro Martínez. Lowe also no-hit the Tampa Bay Devil Rays at Fenway Park on April 27 that year, becoming the first pitcher to do so at Fenway Park since Dave Morehead in 1965. Lowe faced just one over the minimum in the game; only a third inning walk to Brent Abernathy separated Lowe from a perfect game.

Lowe posted a 17–7 record despite a 4.47 ERA in 2003. He recorded an improbable save in deciding Game 5 of the 2003 American League Division Series, helped by two clutch strikeouts.

In 2004, he finished 14–12 with a 5.42 ERA in 33 starts. During the postseason he rebounded with a 3–0 record and 1.86 ERA in four games, three of them starts. He was the winner in the final game of all three postseason series—American League Division Series against the Anaheim Angels, American League Championship Series against the New York Yankees, and World Series against the St. Louis Cardinals (where he threw shutout ball for 7 innings in Game 4, to defeat Jason Marquis) — as the Red Sox won their first World Series in 86 years. However, the win against the Angels was coming in relief. Lowe later said that the team would no longer have to hear "1918", a derisive chant mocking the Red Sox's previously most recent title win, at Yankee Stadium.[3][4]

Los Angeles Dodgers

Derek Lowe pitching
Lowe pitching for the Los Angeles Dodgers in 2006.

On January 11, 2005, Lowe finalized a $36 million, four-year contract with the Los Angeles Dodgers.[5] Despite his signing with a new team, Lowe wore a Red Sox uniform, with his career-long number of 32, during the Red Sox World Series ring ceremony on April 11, 2005, after already making a start for the Dodgers.

On August 31, 2005, Lowe nearly pitched the second no-hitter of his career. After giving up a leadoff single to the Cubs' Jerry Hairston, Jr., Lowe did not allow another Chicago hit, picking up a one-hit, two-walk, 7–0 complete game victory while facing only 29 batters.

For the 2008 season, after being the opening day starter for the Dodgers for the last three years, he was moved to the second starting position, behind Brad Penny. Lowe was chosen by manager Joe Torre to start Game 1 of the National League Championship series against the Philadelphia Phillies on October 9, 2008. Lowe opened the game with five scoreless innings.

Both times that the Dodgers acquired Greg Maddux midseason, Lowe performed visibly better afterwards. He indicated that Maddux helped him considerably, and Maddux was often seen sitting next to him in the dugout.[6]

Atlanta Braves

Lowe agreed to a four-year, $60 million deal with the Atlanta Braves during the 2008–09 offseason.[7] Manager Bobby Cox announced that Lowe would start both Opening Day and the Braves home opener for the 2009 season. Lowe beat the Phillies 4–1 on Opening Night, going 8 innings and giving up just 2 hits and 0 runs.[8]

In 2010, Lowe was one of only two active players, along with Liván Hernández, to have played 12 or more seasons without going on the disabled list.[9]

Despite having a mediocre season until August, Lowe was exceptional in September 2010, with a 5–0 record, a 1.77 ERA, 29 strikeouts while walking only three batters, which helped the Braves secure a playoff berth as the NL Wild Card, being one game ahead of the second place Padres at the end of the regular season. For this, Lowe was named National League Pitcher of the Month.[10]

On August 31, 2011, Lowe hit his first home run (in 425 at-bats) off John Lannan of the Washington Nationals.[11]

Cleveland Indians

Derek Lowe on June 29, 2012
Lowe during his stint with the Cleveland Indians in 2012

Following the 2011 season, the Braves traded Lowe to the Cleveland Indians for minor league left-handed relief pitcher Chris Jones. The Braves paid $10 million of Lowe's $15 million salary for the 2012 season.[12] On May 15, 2012 in a road game versus the Minnesota Twins, Lowe recorded his first shutout in seven years and also pitched a complete game in a 5-0 Tribe win, improving his season pitching record to 6-1. Lowe did not record a strikeout in the shutout, becoming the first pitcher to do so since 2002.[13]

The Indians designated Lowe for assignment on August 1 to make room for Corey Kluber. Lowe was 8-10 with a 5.52 ERA in 21 starts and 119 innings pitched.[14] The Indians released Lowe on August 10.[15]

New York Yankees

Derek Lowe on September 6, 2012
Lowe with the New York Yankees

On August 12, 2012, Lowe signed with the New York Yankees.[16] He made his Yankees debut on August 13 pitching 4 scoreless innings of relief and got his first regular season save since 2001.[17] Lowe was also on the team's postseason roster until the team lost to the Detroit Tigers in the 2012 ALCS. Lowe became a free agent after the 2012 season ended.

Texas Rangers

On March 6, 2013, Lowe signed a minor league contract with the Texas Rangers.[18] He made the team's major league roster, and was with the Rangers on opening day.[19] He was designated for assignment on May 20, 2013.[20][21]

On June 9, 2013, sports journalist Nick Cafardo reported that Lowe appeared to have retired. According to Cafardo, Lowe told his agent, Scott Boras, not to approach any teams to see if they have any interest in Lowe.[22]

Lowe officially announced his retirement July 18, 2013.[23]

Lowe was eligible to be elected into the Hall of Fame in 2019, but received less than 5% of the vote and became ineligible for the 2020 ballot.

Scouting report

Lowe was a sinkerball pitcher, throwing the pitch over 60% of the time. He also threw a fastball, curveball and a slider.[24][25]

Personal life

Lowe has advocated for various causes to fight cancer. Himself a survivor of squamous cell carcinoma,[26] Lowe has worked with the Melanoma Foundation of New England,[27] the National Council on Skin Cancer Prevention,[28] and The Prostate Cancer Foundation.[29] Lowe was diagnosed with attention deficit disorder and received permission to treat it with Adderall, a substance banned by Major League Baseball.[30]

Lowe was charged with fourth-degree domestic violence by King County police in 1997 after his girlfriend claimed that he struck her. Lowe was released on $1,000 bond the next day, and he allegedly violated a no-contact order by returning to her home shortly after his release.[31] Lowe entered counseling as a result.[32]

Carolyn Hughes, who covered the Dodgers for Fox Sports West, was suspended pending an investigation into a potential relationship between her and Lowe during his tenure with the Dodgers. Shortly thereafter, Lowe filed for divorce from Trinka Lowe, his wife of seven years, with whom he fathered three children.[33] Hughes's husband had also filed for divorce. In the aftermath, Hughes ended her broadcasting career and she and Lowe continued their relationship. They were married on December 13, 2008 at The Henry Ford in Dearborn, Michigan.[34]

On April 28, 2011, Lowe was arrested and charged with driving under the influence, reckless driving, and improper lane change after he was spotted drag racing down an Atlanta street with another car. The trooper who stopped him detected an odor of alcohol and administered a field sobriety test, which resulted in Lowe's arrest. Lowe declined to take a breath test before he was released after posting bail. The other driver was not charged with any offense and was released.[35] On May 26, 2011, both the DUI charge and the reckless driving charge were dismissed by City of Atlanta Solicitor-General Raines Carter, and Lowe entered a nolo contendere (no contest) plea to violating basic motor vehicle rules.[36]

Lowe finished second to Mark Mulder in the July 2017 American Century Championships celebrity golf tournament.[37]

See also


  1. ^ a b c d e f g "Baseball the right choice for Lowe". March 11, 2003. Retrieved August 13, 2012.
  2. ^ "Slocumb loses, leaves After Sox fall, he's dealt to Mariners". August 1, 1997. Retrieved October 10, 2012.
  3. ^ Curry, Jack (October 28, 2004). "Kiss That Curse Goodbye". The New York Times. Retrieved August 12, 2012.
  4. ^ Dodd, Mike (October 28, 2004). "Finally! Red Sox win World Series". USA Today. Retrieved September 9, 2009.
  5. ^ "New ace has 52 wins in past 3 seasons". Associated Press. January 13, 2005. Retrieved February 7, 2009.
  6. ^ "Lowe drops duel to Cardinals". Retrieved August 12, 2012.
  7. ^ "Braves agree to terms with pitcher Derek Lowe on four-year contract | Official Info". January 15, 2009. Retrieved July 21, 2010.
  8. ^ O'Brien, David (January 13, 2009). "Atlanta Braves news". Retrieved July 21, 2010.
  9. ^ Rogers, Carroll (May 1, 2009). "Atlanta News, Sports, Atlanta Weather, Business News". Retrieved July 21, 2010.
  10. ^ Hall, James. "Lowe, Price named Pitchers of Month". Retrieved August 6, 2011.
  11. ^ O'Brien, David (September 1, 2011). "Derek Lowe homers, Craig Kimbrel gets record save". Retrieved August 12, 2012.
  12. ^ Beck, Jason (October 31, 2011). "Tribe acquires veteran Lowe from Braves". Archived from the original on November 2, 2011. Retrieved October 31, 2011.
  13. ^ Sendell, Nate (May 15, 2012). "Tribe chugs past Twins behind Lowe's shutout". Retrieved May 16, 2012.
  14. ^ Hoynes, Paul (August 1, 2012). "Derek Lowe designated for assignment by Tribe". Plain Dealer. Retrieved August 2, 2012.
  15. ^ "Indians release Derek Lowe | HardballTalk". August 9, 2012. Retrieved August 13, 2012.
  16. ^ "Yankees sign veteran right-hander Derek Lowe | News". Retrieved October 10, 2012.
  17. ^ "Given fresh start, Lowe makes immediate impact | News". Retrieved October 10, 2012.
  18. ^ Evan Grant, Rangers agree to terms with RHP Derek Lowe on minor league deal, March 6, 2013
  19. ^ Aaron Gleeman, NBC Sports, Derek Lowe makes the Rangers as a middle reliever, March 26, 2013
  20. ^ "Rangers recall Josh Lindblom; Derek Lowe designated for assignment". May 20, 2013. Retrieved September 23, 2014.
  21. ^ "Rangers turn Lowe loose to make room for Lindblom". Associated Press. May 20, 2013. Retrieved September 23, 2014.
  22. ^ Nick Cafardo, Boston Globe, Four of MLB's Preseason Favorites Are Duds, June 9, 2013
  23. ^ Zach Stoloff, NESN, Derek Lowe Announces Retirement, July 18, 2013
  24. ^ Robert Pike, Shut Down Inning, Derek Lowe and the Sinker Archived June 30, 2013, at, March 24, 2013
  25. ^ Kevin Sipe, Bleacher Report, Derek Lowe: How the Atlanta Braves' Pitcher Went From Has-Been to Ace, April 8, 2011
  26. ^ "Lowe now 'nose' to use sunscreen | News". Boston Red Sox. MLB. February 14, 2003. Archived from the original on June 6, 2011. Retrieved July 21, 2010.
  27. ^ "News & Events – MMF Newsletter" (PDF). Archived from the original (PDF) on July 27, 2011. Retrieved July 21, 2010.
  28. ^ Ian Browne. "Notes: Offense taking shape | News". Retrieved August 12, 2012.
  29. ^ "Derek Lowe Urges Men To Get Prostate Cancer Checkups". Bleacher Report. September 13, 2009. Retrieved July 21, 2010.
  30. ^ "Dodgers' Lowe has ADD, allowed to take banned drug – MLB – ESPN". April 5, 2006. Retrieved July 21, 2010.
  31. ^ Dick, Bob (August 23, 1997). "Another problem for Sox". The New Bedford Standard-Times. Archived from the original on January 29, 1999. Retrieved June 24, 2006.
  32. ^ "Pawsox's Lowe in counseling for domestic violence". The Providence Journal. August 23, 1997. Retrieved August 13, 2012. (subscription required)
  33. ^ "DODGERS' LOWE GETS PERSONAL ABOUT FUTURE". San Jose Mercury News. March 4, 2006. p. 2D. Retrieved August 12, 2012. (subscription required)
  34. ^ "Lowe unlikely to return to Dodgers | News". June 19, 2012. Retrieved August 12, 2012.
  35. ^ "Police: Braves' Lowe racing before charged with DUI". Usatoday.Com. April 29, 2011. Retrieved August 12, 2012.
  36. ^ Boone, Christian (May 26, 2011). "DUI, reckless-driving charges against Derek Lowe dropped". Retrieved August 12, 2012.
  37. ^ Ex-MSU pitcher Mark Mulder wins celebrity golf title; Derek Lowe second

External links


1-Diazidocarbamoyl-5-azidotetrazole (nicknamed azidoazide azide by chemistry blogger and medicinal chemist Derek Lowe) is a heterocyclic inorganic compound with the formula C2N14. It is an extremely dangerous and sensitive explosive, to the point of detonating from no obvious stimuli. This results in the near impossibility of conducting any sort of analysis of 1-Diazidocarbamoyl-5-azidotetrazole.

1999 American League Division Series

The 1999 American League Division Series (ALDS), the opening round of the 1999 American League playoffs, began on Tuesday, October 5, and ended on Monday, October 11, with the champions of the three AL divisions—along with a "wild card" team—participating in two best-of-five series. The teams, which were identical to those qualifying in 1998, were:

(1) New York Yankees (Eastern Division champion, 98–64) vs. (3) Texas Rangers (Western Division champion, 95–67): Yankees win the series, 3–0.

(2) Cleveland Indians (Central Division champion, 97–65) vs. (4) Boston Red Sox (Wild Card, 94–68): Red Sox win the series, 3–2.The Yankees rolled over the Rangers, who scored 945 runs in 1999, for the second straight year three games to none. The Red Sox battled back down two games to none against a Cleveland Indians team that was the first to score 1,000 runs in a season in nearly 50 years and won the Series three games to two, thanks to Pedro Martínez. The Yankees would go on to defeat the Red Sox four games to one in their first-ever meeting in the postseason in the AL Championship Series, and would then go on to sweep the National League champion Atlanta Braves in the 1999 World Series.

2000 Boston Red Sox season

The 2000 Boston Red Sox season was the 100th season in the franchise's Major League Baseball history. The Red Sox finished second in the American League East with a record of 85 wins and 77 losses, 2½ games behind the New York Yankees. The Red Sox did not qualify for the postseason, as the AL wild card was the Seattle Mariners who had finished second in the American League West with a record of 91–71.

2002 Boston Red Sox season

The 2002 Boston Red Sox season was the 102nd season in the franchise's Major League Baseball history. The Red Sox finished second in the American League East with a record of 93 wins and 69 losses, 10½ games behind the New York Yankees. The Red Sox did not qualify for the postseason, as the AL wild card was the Anaheim Angels who had finished second in the American League West with a record of 99–63.

2002 Major League Baseball All-Star Game

The 2002 Major League Baseball All-Star Game was the 73rd playing of the midsummer classic between the all-stars of the American League (AL) and National League (NL), the two leagues that make up Major League Baseball. The game was held on July 9, 2002 at Miller Park in Milwaukee, Wisconsin, the home of the Milwaukee Brewers of the NL. The game controversially ended with a 7–7 tie due to both teams running out of available pitchers. Beginning the next year, home field advantage in the World Series would be awarded to the winning league to prevent ties (this rule would stay until 2016).

No player was awarded the Most Valuable Player (MVP) Award due to the game ending in a tie. The roster selection for the 2002 game marked the inaugural All-Star Final Vote competition (then known as "The All-Star 30th Man" competition). Johnny Damon and Andruw Jones represented the American and National Leagues as a result of this contest.

2003 American League Championship Series

The 2003 American League Championship Series (ALCS) was played between the Boston Red Sox and the New York Yankees from October 8 to 16, 2003. The Yankees won the series four games to three to advance to the World Series, where they lost in six games to the National League champion Florida Marlins.

2003 American League Division Series

The 2003 American League Division Series (ALDS), the opening round of the 2003 American League playoffs, began on Tuesday, September 30, and ended on Monday, October 6, with the champions of the three AL divisions—along with a "wild card" team—participating in two best-of-five series. The teams were:

(1) New York Yankees (Eastern Division champion, 101–61) vs. (3) Minnesota Twins (Central Division champion, 90–72): Yankees win series, 3–1.

(2) Oakland Athletics (Western Division champion, 96–66) vs. (4) Boston Red Sox (Wild Card, 95–67): Red Sox win series, 3–2.The Yankees and Red Sox went on to meet in the AL Championship Series, for the right to advance to the 2003 World Series against the National League champion Florida Marlins.

2004 American League Championship Series

The 2004 American League Championship Series was the Major League Baseball playoff series to decide the American League champion for the 2004 season, and the right to play in the 2004 World Series. A rematch of the 2003 American League Championship Series, it was played between the Boston Red Sox and New York Yankees, at Fenway Park and the original Yankee Stadium, from October 12 to 20, 2004. The Red Sox became the first (and so far only) team in MLB history to come back from a 3–0 deficit to win a seven-game series. The Red Sox, who had won the AL wild card, defeated the Anaheim Angels in the American League Division Series to reach the ALCS, while the Yankees, who had won the AL East with the best record in the AL, defeated the Minnesota Twins.

In Game 1, Yankees pitcher Mike Mussina pitched a perfect game through six innings, while the Red Sox recovered from an eight-run deficit to close within one run before the Yankees eventually won. A home run by John Olerud helped the Yankees win Game 2. The Yankees gathered 22 hits in Game 3 on their way to an easy win. The Yankees led Game 4 by one run in the ninth inning, but a steal of second base by Red Sox base runner Dave Roberts and a single by Bill Mueller off Yankees closer Mariano Rivera tied the game. A home run by David Ortiz then won it for the Red Sox in extra innings. Ortiz also won Game 5 with a single in the fourteenth inning. Curt Schilling pitched seven innings in Game 6 for the Red Sox, during which time his sock became soaked in blood due to an injury in his ankle. Game 7 featured the Red Sox paying back New York for their Game 3 blowout with a dominating performance on the road, anchored by Derek Lowe and bolstered by two Johnny Damon home runs, one a grand slam. David Ortiz was named the Most Valuable Player of the series.The Red Sox would go on to sweep the St. Louis Cardinals in the World Series, winning their first World Series championship in 86 years and ending the Curse of the Bambino.

2005 Los Angeles Dodgers season

In 2005, the Los Angeles Dodgers suffered from a rash of injuries to key players such as closer Éric Gagné, shortstop César Izturis and outfielder J. D. Drew and fell to their second worst record in Los Angeles history, finishing in fourth place in the Western Division of the National League. After the season, manager Jim Tracy and General Manager Paul DePodesta were both fired and the team was torn apart. This was also the last season to be broadcast on KCOP (13).

2005 Major League Baseball draft

The 2005 First-Year Player Draft, Major League Baseball's annual amateur draft, was held on June 7 and 8. It was conducted via conference call with representatives from each of the league's 30 teams. It is widely considered to be one of the best drafts in recent memory.Source: Major League Baseball 2005 Official Draft Site

2010 Atlanta Braves season

The 2010 Atlanta Braves season was the franchise's 45th season in Atlanta along with the 135th season in the National League and 140th overall. It featured the Braves' attempt to reclaim a postseason berth for the first time since 2005. The Braves once again were skippered by Bobby Cox, in his 25th and final overall season managing the team. It was their 45th season in Atlanta, and the 135th of the franchise. Finishing the season with a 91–71 record, the Braves won the NL Wild Card, only to be eliminated in the NLDS by the San Francisco Giants in four games.

Chemistry World

Chemistry World is a monthly chemistry news magazine published by the Royal Society of Chemistry. The magazine addresses current events in world of chemistry including research, international business news and government policy as it affects the chemical science community, plus the best product applications. It features regular columns by Philip Ball, Derek Lowe, Andrea Sella, Raychelle Burks and Mark Peplow. The magazine is sent to all members of the Royal Society of Chemistry and is included in the cost of membership. In August 2016, the magazine began offering a "soft" paywall option, where a limited amount of content is made available free to all unregistered readers.

Chemistry World is supported by three podcasts: the Chemistry World Magazine Podcast, Chemistry in its Element and the Chemistry World Book Club podcast.

According to the Journal Citation Reports, the journal has a 2011 impact factor of 0.159, ranking it 146th out of 154 journals in the category "Chemistry, Multidisciplinary".

Derek Lowe (chemist)

Derek Lowe is a medicinal chemist working on preclinical drug discovery in the pharmaceutical industry, and has written a blog about his field called "In the Pipeline" since 2002.Lowe (born in Harrisburg, Arkansas) got his BA from Hendrix College and his PhD in organic chemistry from Duke University on synthesis of natural products, before spending time in Germany on a Humboldt Fellowship.Lowe was the one of the first people to blog from inside the pharmaceutical industry (he talked to his supervisor and the company legal department before starting), and one of the first science bloggers. By 2006, his blog had between 3,000 and 4,000 visitors per day during the workweek; he covered business matters, trends and issues in medicinal chemistry, and legal matters like patent law and regulation. At that time he was working at a pharmaceutical chemistry doing hit to lead medical chemistry work. As of 2010 his blog received between 15,000 and 20,000 page views on a typical weekday. His response to a 2013 article in Buzzfeed that propagated chemophobia was widely cited.He serves on the editorial board of ACS Medicinal Chemistry Letters and on the advisory board of Chemical & Engineering News.As of 2018 he was working at Novartis; formerly he had worked for 10 years at Vertex, 9 years at Bayer, and 8 years at Schering-Plough.


Lowe, Derek B. (2016). The Chemistry Book: From Gunpowder to Graphene, 250 Milestones in the History of Chemistry. Sterling. ISBN 9781454911807.Selected scientific papersGreenlee, W; Clader, J; et al. (April 2001). "Muscarinic agonists and antagonists in the treatment of Alzheimer's disease". Farmaco (Societa Chimica Italiana : 1989). 56 (4): 247–50. PMID 11421251.

Lowe, DB; Magnuson, S; et al. (21 June 2004). "In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase". Bioorganic & Medicinal Chemistry Letters. 14 (12): 3155–9. doi:10.1016/j.bmcl.2004.04.015. PMID 15149665.

Rudolph, J; Esler, WP; et al. (18 October 2007). "Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity". Journal of Medicinal Chemistry. 50 (21): 5202–16. doi:10.1021/jm070071+. PMID 17887659.

Arrowsmith, CH; Audia, JE; et al. (August 2015). "The promise and peril of chemical probes". Nature Chemical Biology. 11 (8): 536–41. doi:10.1038/nchembio.1867. PMC 4706458. PMID 26196764.Selected blogs or commentary

Lowe, Derek (7 February 2002). "The Latest Thing". In the Pipeline. (1st post)

Lowe, Derek (7 May 2010). "Molecular modelling's $10-million comeback?". Nature. doi:10.1038/news.2010.223.

Lowe, Derek (23 February 2010). "Things I Won't Work With: Dioxygen Difluoride". In the Pipeline. Cited in "Pressure Cooker". What-if xkcd. April 9, 2013.

Lowe, Derek (24 September 2010). "Avandia Goes Down: A Research Rant". In the Pipeline.

Lowe, Derek (21 June 2013). "Eight Toxic Foods: A Little Chemical Education". In the Pipeline., "Eight Toxic Foods: The Aftermath". In the Pipeline. 24 June 2013.

Lowe, Derek (24 August 2016). "Drug Mergers Hurt in Every Direction (Save One)". In the Pipeline.

Lowe, Derek (12 January 2017). "Curcumin Will Waste Your Time". In the Pipeline.

Lowe, Derek (10 January 2018). "Objections to (Some) Drug Discovery AI". In the Pipeline.

Heathcliff Slocumb

Heath "Heathcliff" Slocumb (born June 7, 1966) is a former Major League Baseball relief pitcher. He batted and threw right-handed.

In a 10-year career, Slocumb played with the Chicago Cubs, Cleveland Indians, Philadelphia Phillies, Boston Red Sox, Seattle Mariners, Baltimore Orioles, St. Louis Cardinals, and San Diego Padres.

An All-Star selection in 1995, Slocumb compiled a career 28-37 record with 513 strikeouts and a 4.08 ERA in 631 innings. He collected 98 saves, including 32 for the Phillies in 1995 and 31 with Boston in 1996.

Slocumb was traded in mid-1997 from Boston to Seattle for pitcher Derek Lowe and catcher Jason Varitek, in what is often cited in retrospect as one of the most one-sided trades in baseball history. At the time, Lowe had pitched in only 12 major-league games with an ERA of nearly 7, and Varitek had never played in the majors. However, Lowe and Varitek both went on to make multiple All-Star teams and were major contributors to the 2004 World Champion Red Sox. In 2005, Varitek was named captain of the Red Sox. Although Slocumb helped the Mariners make the playoffs in 1997, his career had dissipated significantly by 1998 and he was never effective again.

List of Boston Red Sox no-hitters

The Boston Red Sox are a Major League Baseball franchise based in Boston, Massachusetts, also known in their early years as the "Boston Americans" (1901–07). They play in the American League East division. Pitchers for the Red Sox have thrown 18 no-hitters in franchise history.A no-hitter is officially recognized by Major League Baseball "when a pitcher (or pitchers) allows no hits during the entire course of a game, which consists of at least nine innings. In a no-hit game, a batter may reach base via a walk, an error, a hit by pitch, a passed ball or wild pitch on strike three, or catcher's interference." (No-hitters of less than nine complete innings were previously recognized by the league as official; however, several rule alterations in 1991 changed the rule to its current form.) A no-hitter is rare enough that one team in Major League Baseball, the San Diego Padres, has never had a pitcher accomplish the feat. The New York Mets' first no-hitter (pitched by Johan Santana) came on June 1, 2012, in the team's 8,021st game and 51st season.One perfect game, a special subcategory of no-hitter, has been pitched in Red Sox history. As defined by Major League Baseball, "in a perfect game, no batter reaches any base during the course of the game." Every opposing batter is retired. This feat was achieved by Cy Young in 1904. Young's perfect game, pitched on May 5, 1904, also was the first no-hitter in Red Sox history; the most recent Red Sox no-hitter was thrown by Jon Lester on May 19, 2008.Two pitchers have thrown more than one no-hitter in a Red Sox uniform, Hall of Famer Cy Young and Dutch Leonard. Thirteen of the Red Sox no-hitters were thrown at home (the first four at the Huntington Avenue Grounds and the other nine at Fenway Park) and five on the road. Two were thrown in April, two in May, five in June, two in July, three in August, and four in September. The longest interval between Red Sox no-hitters was 35 years, 6 months, and 18 days, between the games pitched by Dave Morehead, on September 16, 1965 and Hideo Nomo, on April 4, 2001. The shortest interval between Red Sox no-hitters was merely 1 month and 6 days, between the games pitched by Earl Wilson on June 26, 1962 and Bill Monbouquette on August 1, 1962.The Red Sox have no-hit the Chicago White Sox and Baltimore Orioles (formerly the "St. Louis Browns") the most: four times each. The White Sox were no-hit by Jesse Tannehill in 1904, Bill Dinneen in 1905, Parnell in 1956, and Monbouquette in 1962. The Browns and Orioles were no-hit by Smokey Joe Wood in 1911, Leonard in 1916, Hideo Nomo in 2001, and Clay Buchholz in 2007. The Red Sox have won all of their no-hitters (three times in major league history a team has thrown a nine-inning no-hitter and lost the game). The most baserunners allowed in a Red Sox no-hitter was five, by Dutch Leonard in 1918. Of the 18 Red Sox no-hitters, four have been won by a score of 4–0 and another four by a score of 2–0, making those final scores more common than any other results. The largest margin of victory in a Red Sox no-hitter was 10–0, in wins by Derek Lowe in 2002 and Clay Buchholz in 2007. The smallest margin of victory was 1–0, Monbouquette's no-hitter in 1962.

12 different managers have led the team during the franchise's 18 no-hitters. 15 different home plate umpires presided over the franchise's 18 no-hitters. Jason Varitek has caught the last 4 of the Red Sox's No-hitters, a Major League record for No-hitters caught by one catcher.

List of Los Angeles Dodgers Opening Day starting pitchers

The Los Angeles Dodgers are a Major League Baseball (MLB) franchise based in Los Angeles. They play in the National League West division. The first game of the new baseball season for a team is played on Opening Day, and being named the Opening Day starter is an honor, which is often given to the player who is expected to lead the pitching staff that season, though there are various strategic reasons why a team's best pitcher might not start on Opening Day. The Dodgers have used 22 different Opening Day starting pitchers in their 61 seasons in Los Angeles. The 22 starters have a combined Opening Day record of 27 wins, 26 losses and 8 no decisions.The Dodgers started playing in Los Angeles in 1958, after moving from Brooklyn. The first Opening Day game for the Dodgers in Los Angeles was played in San Francisco against the San Francisco Giants on April 15, 1958. California native Don Drysdale was the Dodgers' Opening Day starting pitcher that day, in a game the Dodgers lost 8–0. Dodgers starting pitchers won both of their Opening Day starts in their first home ballpark in Los Angeles, Los Angeles Memorial Coliseum.Kershaw's eight Opening Day starts for the Dodgers from 2011 to 2018 are the most ever by a Dodgers starter, one more than Don Drysdale and Don Sutton. Fernando Valenzuela, Ramón Martínez and Orel Hershiser have had at least four Opening Day starts, with six, five and four respectively. Hall of Famer Sandy Koufax, who won three Cy Young Awards during the 1960s, only made one Opening Day start for the Dodgers, in 1964. Drysdale and Kershaw are also tied for the Los Angeles Dodgers record for most wins as an Opening Day starter, with five wins. Drysdale also had two loses while Kershaw has one loss.Koufax (1964), Chan Ho Park (2001), Brad Penny (2008) and Hiroki Kuroda (2009) are the only Los Angeles Dodgers Opening Day starting pitchers to have won all their Opening Day decisions, Martinez and Derek Lowe share the Los Angeles Dodgers record for most Opening Day losses, with three. The Los Angeles Dodgers won the World Series championship in 1959, 1963, 1965, 1981 and 1988. Drysdale (1959, 1963 and 1965), and Fernando Valenzuela (1981 and 1988) were the Dodgers' Opening Day starting pitchers those years. The Dodgers' starting pitcher won the Opening Day game in 1963, 1965 and 1981, but lost in 1959 and 1988.

Max Gergel

Max Gergel was an American chemist. He graduated with a BS in chemical engineering from the University of South Carolina in 1942 and founded the Columbia Organic Chemical Company in 1944. He died in Columbia, South Carolina on July 5, 2017, aged 96.The first volume of his autobiography Excuse Me Sir, Would You Like to Buy a Kilo of Isopropyl Bromide? was published in 1977. Research chemist Derek Lowe described the book as an "extraordinary memoir".

Port City Roosters

The Port City Roosters were a minor league baseball team based in Wilmington, North Carolina. The team, which played in the Southern League, was the Double-A affiliate of the Seattle Mariners major-league club. The Roosters played in Brooks Field on the campus of the University of North Carolina Wilmington. Opened in 1989, the park seats 3,000 fans.

The team began play in 1995, after the Nashville Xpress was relocated to Wilmington. Following the 1996 season, the Roosters franchise was relocated to Mobile, Alabama, and resumed play as the Mobile BayBears. Many factors were cited as necessitating the move, including an inadequate stadium, well below Minor League Baseball standards for Class AA, and low attendance.

The Roosters games were broadcast locally on WAAV 980. David Kelly and Mike Ferreri did the play-by-play. Kelly is now a sports anchor/reporter at KMSB-TV and KOLD-TV in Tucson, Arizona. Ferreri is the Sports Director at KOMO-TV in Seattle.

Among the better-known former major leaguers who wore the Roosters uniform were Red Sox captain Jason Varitek, pitchers Derek Lowe and Ryan Franklin, infielder Desi Relaford and outfielders José Cruz, Jr. and Raúl Ibañez.

Awards and achievements
Preceded by
Bud Smith
No-hitter pitcher
April 27, 2002
Succeeded by
Kevin Millwood
Preceded by
Roger Clemens
American League All-Star Game Starting Pitcher
Succeeded by
Esteban Loaiza
Preceded by
Hideo Nomo
Los Angeles Dodgers Opening Day
Starting pitcher

Succeeded by
Brad Penny


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