Dichlorodiphenyltrichloroethane, commonly known as DDT, is a colorless, tasteless, and almost odorless crystalline chemical compound, an organochlorine, originally developed as an insecticide, and ultimately becoming infamous for its environmental impacts. It was first synthesized in 1874 by the Austrian chemist Othmar Zeidler. DDT's insecticidal action was discovered by the Swiss chemist Paul Hermann Müller in 1939. DDT was used in the second half of World War II to control malaria and typhus among civilians and troops. Müller was awarded the Nobel Prize in Physiology or Medicine "for his discovery of the high efficiency of DDT as a contact poison against several arthropods" in 1948.
By October 1945, DDT was available for public sale in the United States. Although it was promoted by government and industry for use as an agricultural and household pesticide, there were also concerns about its use from the beginning. Opposition to DDT was focused by the 1962 publication of Rachel Carson's book Silent Spring. It cataloged environmental impacts that coincided with widespread use of DDT in agriculture in the United States, and it questioned the logic of broadcasting potentially dangerous chemicals into the environment with little prior investigation of their environmental and health effects. The book claimed that DDT and other pesticides had been shown to cause cancer and that their agricultural use was a threat to wildlife, particularly birds. Its publication was a seminal event for the environmental movement and resulted in a large public outcry that eventually led, in 1972, to a ban on DDT's agricultural use in the United States. A worldwide ban on agricultural use was formalized under the Stockholm Convention on Persistent Organic Pollutants, but its limited and still-controversial use in disease vector control continues, because of its effectiveness in reducing malarial infections, balanced by environmental and other health concerns.
Along with the passage of the Endangered Species Act, the United States ban on DDT is a major factor in the comeback of the bald eagle (the national bird of the United States) and the peregrine falcon from near-extinction in the contiguous United States.
|Preferred IUPAC name
3D model (JSmol)
|Molar mass||354.48 g·mol−1|
|Melting point||108.5 °C (227.3 °F; 381.6 K)|
|Boiling point||260 °C (500 °F; 533 K) (decomposes)|
|25 μg/L (25 °C)|
|Main hazards||Toxic, dangerous to the environment, likely carcinogenic|
|GHS signal word||Danger|
|H301, H351, H372, H410|
|P201, P202, P260, P264, P270, P273, P281, P301+310, P308+313, P314, P321, P330, P391, P405, P501|
|Flash point||72–77 °C; 162–171 °F; 345–350 K |
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|113–800 mg/kg (rat, oral)|
250 mg/kg (rabbit, oral)
135 mg/kg (mouse, oral)
150 mg/kg (guinea pig, oral)
|US health exposure limits (NIOSH):|
|TWA 1 mg/m3 [skin]|
|Ca TWA 0.5 mg/m3|
IDLH (Immediate danger)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
DDT is similar in structure to the insecticide methoxychlor and the acaricide dicofol. It is highly hydrophobic and nearly insoluble in water but has good solubility in most organic solvents, fats and oils. DDT does not occur naturally and is synthesised by consecutive Friedel–Crafts reactions between chloral (CCl
3CHO) and two equivalents of chlorobenzene (C
5Cl), in the presence of an acidic catalyst. DDT has been marketed under trade names including Anofex, Cezarex, Chlorophenothane, Dicophane, Dinocide, Gesarol, Guesapon, Guesarol, Gyron, Ixodex, Neocid, Neocidol and Zerdane; INN is clofenotane.
Commercial DDT is a mixture of several closely–related compounds. Due to the nature of the chemical reaction used to synthesize DDT, several combinations of ortho and para arene substitution patterns are formed. The major component (77%) is the desired p,p' isomer. The o,p' isomeric impurity is also present in significant amounts (15%). Dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) make up the balance of impurities in commercial samples. DDE and DDD are also the major metabolites and environmental breakdown products. DDT, DDE and DDD are sometimes referred to collectively as DDX.
DDT has been formulated in multiple forms, including solutions in xylene or petroleum distillates, emulsifiable concentrates, water-wettable powders, granules, aerosols, smoke candles and charges for vaporizers and lotions.
From 1950 to 1980, DDT was extensively used in agriculture – more than 40,000 tonnes each year worldwide – and it has been estimated that a total of 1.8 million tonnes have been produced globally since the 1940s. In the United States, it was manufactured by some 15 companies, including Monsanto, Ciba, Montrose Chemical Company, Pennwalt, and Velsicol Chemical Corporation. Production peaked in 1963 at 82,000 tonnes per year. More than 600,000 tonnes (1.35 billion pounds) were applied in the US before the 1972 ban. Usage peaked in 1959 at about 36,000 tonnes.
In 2009, 3,314 tonnes were produced for malaria control and visceral leishmaniasis. India is the only country still manufacturing DDT, and is the largest consumer. China ceased production in 2007.
In insects, DDT opens sodium ion channels in neurons, causing them to fire spontaneously, which leads to spasms and eventual death. Insects with certain mutations in their sodium channel gene are resistant to DDT and similar insecticides. DDT resistance is also conferred by up-regulation of genes expressing cytochrome P450 in some insect species, as greater quantities of some enzymes of this group accelerate the toxin's metabolism into inactive metabolites. (The same enzyme family is up-regulated in mammals too, e.g., in response to ethanol consumption.) Genomic studies in the model genetic organism Drosophila melanogaster revealed that high level DDT resistance is polygenic, involving multiple resistance mechanisms.
|"Episode 207: DDT", Science History Institute|
DDT was first synthesized in 1874 by Othmar Zeidler under the supervision of Adolf von Baeyer. It was further described in 1929 in a dissertation by W. Bausch and in two subsequent publications in 1930. The insecticide properties of "multiple chlorinated aliphatic or fat-aromatic alcohols with at least one trichloromethane group" were described in a patent in 1934 by Wolfgang von Leuthold. DDT's insecticidal properties were not, however, discovered until 1939 by the Swiss scientist Paul Hermann Müller, who was awarded the 1948 Nobel Prize in Physiology and Medicine for his efforts.
DDT is the best-known of several chlorine-containing pesticides used in the 1940s and 1950s. With pyrethrum in short supply, DDT was used extensively during World War II by the Allies to control the insect vectors of typhus – nearly eliminating the disease in many parts of Europe. In the South Pacific, it was sprayed aerially for malaria and dengue fever control with spectacular effects. While DDT's chemical and insecticidal properties were important factors in these victories, advances in application equipment coupled with competent organization and sufficient manpower were also crucial to the success of these programs.
In 1955, the World Health Organization commenced a program to eradicate malaria in countries with low to moderate transmission rates worldwide, relying largely on DDT for mosquito control and rapid diagnosis and treatment to reduce transmission. The program eliminated the disease in "North America, Europe, the former Soviet Union", and in "Taiwan, much of the Caribbean, the Balkans, parts of northern Africa, the northern region of Australia, and a large swath of the South Pacific" and dramatically reduced mortality in Sri Lanka and India.
However, failure to sustain the program, increasing mosquito tolerance to DDT, and increasing parasite tolerance led to a resurgence. In many areas early successes partially or completely reversed, and in some cases rates of transmission increased. The program succeeded in eliminating malaria only in areas with "high socio-economic status, well-organized healthcare systems, and relatively less intensive or seasonal malaria transmission".
DDT was less effective in tropical regions due to the continuous life cycle of mosquitoes and poor infrastructure. It was not applied at all in sub-Saharan Africa due to these perceived difficulties. Mortality rates in that area never declined to the same dramatic extent, and now constitute the bulk of malarial deaths worldwide, especially following the disease's resurgence as a result of resistance to drug treatments and the spread of the deadly malarial variant caused by Plasmodium falciparum. Eradication was abandoned in 1969 and attention instead focused on controlling and treating the disease. Spraying programs (especially using DDT) were curtailed due to concerns over safety and environmental effects, as well as problems in administrative, managerial and financial implementation. Efforts shifted from spraying to the use of bednets impregnated with insecticides and other interventions.
By October 1945, DDT was available for public sale in the United States, used both as an agricultural pesticide and as a household insecticide. Although its use was promoted by government and the agricultural industry, US scientists such as FDA pharmacologist Herbert O. Calvery expressed concern over possible hazards associated with DDT as early as 1944. In 1947, Dr. Bradbury Robinson, a physician and nutritionist practicing in St. Louis, Michigan, warned of the dangers of using the pesticide DDT in agriculture. DDT had been researched and manufactured in St. Louis by the Michigan Chemical Corporation, later purchased by Velsicol Chemical Corporation, and had become an important part of the local economy. Citing research performed by Michigan State University in 1946, Robinson, a past president of the local Conservation Club, opined that:
... perhaps the greatest danger from D.D.T. is that its extensive use in farm areas is most likely to upset the natural balances, not only killing beneficial insects in great number but by bringing about the death of fish, birds, and other forms of wild life either by their feeding on insects killed by D.D.T. or directly by ingesting the poison.
As its production and use increased, public response was mixed. At the same time that DDT was hailed as part of the "world of tomorrow," concerns were expressed about its potential to kill harmless and beneficial insects (particularly pollinators), birds, fish, and eventually humans. The issue of toxicity was complicated, partly because DDT's effects varied from species to species, and partly because consecutive exposures could accumulate, causing damage comparable to large doses. A number of states attempted to regulate DDT. In the 1950s the federal government began tightening regulations governing its use. These events received little attention. Women like Dorothy Colson and Mamie Ella Plyler of Claxton, Georgia gathered evidence about DDT's effects and wrote to the Georgia Department of Public Health, the National Health Council in New York City, and other organizations.
In 1957 The New York Times reported an unsuccessful struggle to restrict DDT use in Nassau County, New York, and the issue came to the attention of the popular naturalist-author Rachel Carson. William Shawn, editor of The New Yorker, urged her to write a piece on the subject, which developed into her 1962 book Silent Spring. The book argued that pesticides, including DDT, were poisoning both wildlife and the environment and were endangering human health. Silent Spring was a best seller, and public reaction to it launched the modern environmental movement in the United States. The year after it appeared, President John F. Kennedy ordered his Science Advisory Committee to investigate Carson's claims. The committee's report "add[ed] up to a fairly thorough-going vindication of Rachel Carson’s Silent Spring thesis," in the words of the journal Science, and recommended a phaseout of "persistent toxic pesticides".
DDT became a prime target of the growing anti-chemical and anti-pesticide movements, and in 1967 a group of scientists and lawyers founded the Environmental Defense Fund (EDF) with the specific goal of enacting a ban on DDT. Victor Yannacone, Charles Wurster, Art Cooley and others in the group had all witnessed bird kills or declines in bird populations and suspected that DDT was the cause. In their campaign against the chemical, EDF petitioned the government for a ban and filed lawsuits. Around this time, toxicologist David Peakall was measuring DDE levels in the eggs of peregrine falcons and California condors and finding that increased levels corresponded with thinner shells.
In response to an EDF suit, the U.S. District Court of Appeals in 1971 ordered the EPA to begin the de-registration procedure for DDT. After an initial six-month review process, William Ruckelshaus, the Agency's first Administrator rejected an immediate suspension of DDT's registration, citing studies from the EPA's internal staff stating that DDT was not an imminent danger. However, these findings were criticized, as they were performed mostly by economic entomologists inherited from the United States Department of Agriculture, who many environmentalists felt were biased towards agribusiness and understated concerns about human health and wildlife. The decision thus created controversy.
The EPA held seven months of hearings in 1971–1972, with scientists giving evidence for and against DDT. In the summer of 1972, Ruckelshaus announced the cancellation of most uses of DDT – exempting public health uses under some conditions. Again, this caused controversy. Immediately after the announcement, both EDF and the DDT manufacturers filed suit against EPA. Many in the agricultural community were concerned that food production would be severely impacted, while proponents of pesticides warned of increased breakouts of insect-borne diseases and questioned the accuracy of giving animals high amounts of pesticides for cancer potential. Industry sought to overturn the ban, while EDF wanted a comprehensive ban. The cases were consolidated, and in 1973 the United States Court of Appeals for the District of Columbia Circuit ruled that the EPA had acted properly in banning DDT. During the late 1970s, the EPA also began banning organochlorines, pesticides that were chemically similar to DDT. These included aldrin, dieldrin, chlordane, heptachlor, texaphene, and mirex.
Some uses of DDT continued under the public health exemption. For example, in June 1979, the California Department of Health Services was permitted to use DDT to suppress flea vectors of bubonic plague. DDT continued to be produced in the United States for foreign markets until 1985, when over 300 tons were exported.
In the 1970s and 1980s, agricultural use was banned in most developed countries, beginning with Hungary in 1968 followed by Norway and Sweden in 1970, West Germany and the United States in 1972, but not in the United Kingdom until 1984. By 1991 total bans, including for disease control, were in place in at least 26 countries; for example Cuba in 1970, the US in the 1980s, Singapore in 1984, Chile in 1985 and the Republic of Korea in 1986.
The Stockholm Convention on Persistent Organic Pollutants, which took effect in 2004, put a global ban on several persistent organic pollutants, and restricted DDT use to vector control. The Convention was ratified by more than 170 countries. Recognizing that total elimination in many malaria-prone countries is currently unfeasible absent affordable/effective alternatives, the convention exempts public health use within World Health Organization (WHO) guidelines from the ban. Resolution 60.18 of the World Health Assembly commits WHO to the Stockholm Convention's aim of reducing and ultimately eliminating DDT. Malaria Foundation International states, "The outcome of the treaty is arguably better than the status quo going into the negotiations. For the first time, there is now an insecticide which is restricted to vector control only, meaning that the selection of resistant mosquitoes will be slower than before."
Despite the worldwide ban, agricultural use continued in India, North Korea, and possibly elsewhere. As of 2013 an estimated 3,000 to 4,000 tons of DDT were produced for disease vector control, including 2786 tons in India. DDT is applied to the inside walls of homes to kill or repel mosquitoes. This intervention, called indoor residual spraying (IRS), greatly reduces environmental damage. It also reduces the incidence of DDT resistance. For comparison, treating 40 hectares (99 acres) of cotton during a typical U.S. growing season requires the same amount of chemical as roughly 1,700 homes.
DDT is a persistent organic pollutant that is readily adsorbed to soils and sediments, which can act both as sinks and as long-term sources of exposure affecting organisms. Depending on conditions, its soil half-life can range from 22 days to 30 years. Routes of loss and degradation include runoff, volatilization, photolysis and aerobic and anaerobic biodegradation. Due to hydrophobic properties, in aquatic ecosystems DDT and its metabolites are absorbed by aquatic organisms and adsorbed on suspended particles, leaving little DDT dissolved in the water (however, its half-life in aquatic environments is listed by the National Pesticide Information Center as 150 years). Its breakdown products and metabolites, DDE and DDD, are also persistent and have similar chemical and physical properties. DDT and its breakdown products are transported from warmer areas to the Arctic by the phenomenon of global distillation, where they then accumulate in the region's food web.
Medical researchers in 1974 found a measurable and significant difference in the presence of DDT in human milk between mothers who lived in New Brunswick and mothers who lived in Nova Scotia, "possibly because of the wider use of insecticide sprays in the past".
Because of its lipophilic properties, DDT can bioaccumulate, especially in predatory birds. DDT is toxic to a wide range of living organisms, including marine animals such as crayfish, daphnids, sea shrimp and many species of fish. DDT, DDE and DDD magnify through the food chain, with apex predators such as raptor birds concentrating more chemicals than other animals in the same environment. They are stored mainly in body fat. DDT and DDE are resistant to metabolism; in humans, their half-lives are 6 and up to 10 years, respectively. In the United States, these chemicals were detected in almost all human blood samples tested by the Centers for Disease Control in 2005, though their levels have sharply declined since most uses were banned. Estimated dietary intake has declined, although FDA food tests commonly detect it.
The chemical and its breakdown products DDE and DDD caused eggshell thinning and population declines in multiple North American and European bird of prey species. DDE-related eggshell thinning is considered a major reason for the decline of the bald eagle, brown pelican, peregrine falcon and osprey. However, birds vary in their sensitivity to these chemicals, with birds of prey, waterfowl and song birds being more susceptible than chickens and related species. Even in 2010, California condors that feed on sea lions at Big Sur that in turn feed in the Palos Verdes Shelf area of the Montrose Chemical Superfund site exhibited continued thin-shell problems, though DDT's role in the decline of the California condor is disputed.
The biological thinning mechanism is not entirely understood, but DDE appears to be more potent than DDT, and strong evidence indicates that p,p'-DDE inhibits calcium ATPase in the membrane of the shell gland and reduces the transport of calcium carbonate from blood into the eggshell gland. This results in a dose-dependent thickness reduction. Other evidence indicates that o,p'-DDT disrupts female reproductive tract development, later impairing eggshell quality. Multiple mechanisms may be at work, or different mechanisms may operate in different species.
DDT is an endocrine disruptor. It is considered likely to be a human carcinogen although the majority of studies suggest it is not directly genotoxic. DDE acts as a weak androgen receptor antagonist, but not as an estrogen. p,p'-DDT, DDT's main component, has little or no androgenic or estrogenic activity. The minor component o,p'-DDT has weak estrogenic activity.
DDT is classified as "moderately toxic" by the US National Toxicology Program (NTP) and "moderately hazardous" by WHO, based on the rat oral LD50 of 113 mg/kg. Indirect exposure is considered relatively non-toxic for humans.
Primarily through the tendency for DDT to buildup in areas of the body with high lipid content, chronic exposure can affect reproductive capabilities and the embryo or fetus.
In 2015, the International Agency for Research on Cancer classified DDT as Group 2A "probably carcinogenic to humans". Previous assessments by the U.S. National Toxicology Program classified it as "reasonably anticipated to be a carcinogen" and by the EPA classified DDT, DDE and DDD as class B2 "probable" carcinogens; these evaluations were based mainly on animal studies.
A 2005 Lancet review stated that occupational DDT exposure was associated with increased pancreatic cancer risk in 2 case control studies, but another study showed no DDE dose-effect association. Results regarding a possible association with liver cancer and biliary tract cancer are conflicting: workers who did not have direct occupational DDT contact showed increased risk. White men had an increased risk, but not white women or black men. Results about an association with multiple myeloma, prostate and testicular cancer, endometrial cancer and colorectal cancer have been inconclusive or generally do not support an association. A 2017 review of liver cancer studies concluded that "organochlorine pesticides, including DDT, may increase hepatocellular carcinoma risk".
A 2009 review, whose co-authors included persons engaged in DDT-related litigation, reached broadly similar conclusions, with an equivocal association with testicular cancer. Case–control studies did not support an association with leukemia or lymphoma.
The question of whether DDT or DDE are risk factors in breast cancer has not been conclusively answered. Several meta analyses of observational studies have concluded that there is no overall relationship between DDT exposure and breast cancer risk. The United States Institute of Medicine reviewed data on the association of breast cancer with DDT exposure in 2012 and concluded that a causative relationship could neither be proven nor disproven.
A 2007 case–control study using archived blood samples found that breast cancer risk was increased 5-fold among women who were born prior to 1931 and who had high serum DDT levels in 1963. Reasoning that DDT use became widespread in 1945 and peaked around 1950, they concluded that the ages of 14–20 were a critical period in which DDT exposure leads to increased risk. This study, which suggests a connection between DDT exposure and breast cancer that would not be picked up by most studies, has received variable commentary in third party reviews. One review suggested that "previous studies that measured exposure in older women may have missed the critical period". The National Toxicology Program notes that while the majority of studies have not found a relationship between DDT exposure and breast cancer that positive associations have been seen in a "few studies among women with higher levels of exposure and among certain subgroups of women".
A 2015 case control study identified a link (odds ratio 3.4) between in-utero exposure (as estimated from archived maternal blood samples) and breast cancer diagnosis in daughters. The findings "support classification of DDT as an endocrine disruptor, a predictor of breast cancer, and a marker of high risk".
Malaria remains the primary public health challenge in many countries. In 2015, there were 214 million cases of malaria worldwide resulting in an estimated 438,000 deaths, 90% of which occurred in Africa. DDT is one of many tools to fight the disease. Its use in this context has been called everything from a "miracle weapon [that is] like Kryptonite to the mosquitoes", to "toxic colonialism".
Before DDT, eliminating mosquito breeding grounds by drainage or poisoning with Paris green or pyrethrum was sometimes successful. In parts of the world with rising living standards, the elimination of malaria was often a collateral benefit of the introduction of window screens and improved sanitation. A variety of usually simultaneous interventions represents best practice. These include antimalarial drugs to prevent or treat infection; improvements in public health infrastructure to diagnose, sequester and treat infected individuals; bednets and other methods intended to keep mosquitoes from biting humans; and vector control strategies such as larvaciding with insecticides, ecological controls such as draining mosquito breeding grounds or introducing fish to eat larvae and indoor residual spraying (IRS) with insecticides, possibly including DDT. IRS involves the treatment of interior walls and ceilings with insecticides. It is particularly effective against mosquitoes, since many species rest on an indoor wall before or after feeding. DDT is one of 12 WHO–approved IRS insecticides.
The WHO's anti-malaria campaign of the 1950s and 1960s relied heavily on DDT and the results were promising, though temporary in developing countries. Experts tie malarial resurgence to multiple factors, including poor leadership, management and funding of malaria control programs; poverty; civil unrest; and increased irrigation. The evolution of resistance to first-generation drugs (e.g. chloroquine) and to insecticides exacerbated the situation. Resistance was largely fueled by unrestricted agricultural use. Resistance and the harm both to humans and the environment led many governments to curtail DDT use in vector control and agriculture. In 2006 WHO reversed a longstanding policy against DDT by recommending that it be used as an indoor pesticide in regions where malaria is a major problem.
When it was introduced in World War II, DDT was effective in reducing malaria morbidity and mortality. WHO's anti-malaria campaign, which consisted mostly of spraying DDT and rapid treatment and diagnosis to break the transmission cycle, was initially successful as well. For example, in Sri Lanka, the program reduced cases from about one million per year before spraying to just 18 in 1963 and 29 in 1964. Thereafter the program was halted to save money and malaria rebounded to 600,000 cases in 1968 and the first quarter of 1969. The country resumed DDT vector control but the mosquitoes had evolved resistance in the interim, presumably because of continued agricultural use. The program switched to malathion, but despite initial successes, malaria continued its resurgence into the 1980s.
DDT remains on WHO's list of insecticides recommended for IRS. After the appointment of Arata Kochi as head of its anti-malaria division, WHO's policy shifted from recommending IRS only in areas of seasonal or episodic transmission of malaria, to advocating it in areas of continuous, intense transmission. WHO reaffirmed its commitment to phasing out DDT, aiming "to achieve a 30% cut in the application of DDT world-wide by 2014 and its total phase-out by the early 2020s if not sooner" while simultaneously combating malaria. WHO plans to implement alternatives to DDT to achieve this goal.
South Africa continues to use DDT under WHO guidelines. In 1996, the country switched to alternative insecticides and malaria incidence increased dramatically. Returning to DDT and introducing new drugs brought malaria back under control. Malaria cases increased in South America after countries in that continent stopped using DDT. Research data showed a strong negative relationship between DDT residual house sprayings and malaria. In a research from 1993 to 1995, Ecuador increased its use of DDT and achieved a 61% reduction in malaria rates, while each of the other countries that gradually decreased its DDT use had large increases.
In some areas resistance reduced DDT's effectiveness. WHO guidelines require that absence of resistance must be confirmed before using the chemical. Resistance is largely due to agricultural use, in much greater quantities than required for disease prevention.
Resistance was noted early in spray campaigns. Paul Russell, former head of the Allied Anti-Malaria campaign, observed in 1956 that "resistance has appeared after six or seven years". Resistance has been detected in Sri Lanka, Pakistan, Turkey and Central America and it has largely been replaced by organophosphate or carbamate insecticides, e.g. malathion or bendiocarb.
In many parts of India, DDT is ineffective. Agricultural uses were banned in 1989 and its anti-malarial use has been declining. Urban use ended. One study concluded that "DDT is still a viable insecticide in indoor residual spraying owing to its effectivity in well supervised spray operation and high excito-repellency factor."
Studies of malaria-vector mosquitoes in KwaZulu-Natal Province, South Africa found susceptibility to 4% DDT (WHO's susceptibility standard), in 63% of the samples, compared to the average of 87% in the same species caught in the open. The authors concluded that "Finding DDT resistance in the vector An. arabiensis, close to the area where we previously reported pyrethroid-resistance in the vector An. funestus Giles, indicates an urgent need to develop a strategy of insecticide resistance management for the malaria control programmes of southern Africa."
DDT can still be effective against resistant mosquitoes and the avoidance of DDT-sprayed walls by mosquitoes is an additional benefit of the chemical. For example, a 2007 study reported that resistant mosquitoes avoided treated huts. The researchers argued that DDT was the best pesticide for use in IRS (even though it did not afford the most protection from mosquitoes out of the three test chemicals) because the other pesticides worked primarily by killing or irritating mosquitoes – encouraging the development of resistance. Others argue that the avoidance behavior slows eradication. Unlike other insecticides such as pyrethroids, DDT requires long exposure to accumulate a lethal dose; however its irritant property shortens contact periods. "For these reasons, when comparisons have been made, better malaria control has generally been achieved with pyrethroids than with DDT." In India outdoor sleeping and night duties are common, implying that "the excito-repellent effect of DDT, often reported useful in other countries, actually promotes outdoor transmission".
IRS is effective if at least 80% of homes and barns in a residential area are sprayed. Lower coverage rates can jeopardize program effectiveness. Many residents resist DDT spraying, objecting to the lingering smell, stains on walls, and the potential exacerbation of problems with other insect pests. Pyrethroid insecticides (e.g. deltamethrin and lambda-cyhalothrin) can overcome some of these issues, increasing participation.
A 1994 study found that South Africans living in sprayed homes have levels that are several orders of magnitude greater than others. Breast milk from South African mothers contains high levels of DDT and DDE. It is unclear to what extent these levels arise from home spraying vs food residues. Evidence indicates that these levels are associated with infant neurological abnormalities.
Illegal diversion to agriculture is also a concern as it is difficult to prevent and its subsequent use on crops is uncontrolled. For example, DDT use is widespread in Indian agriculture, particularly mango production and is reportedly used by librarians to protect books. Other examples include Ethiopia, where DDT intended for malaria control is reportedly used in coffee production, and Ghana where it is used for fishing. The residues in crops at levels unacceptable for export have been an important factor in bans in several tropical countries. Adding to this problem is a lack of skilled personnel and management.
A few people and groups have argued that limitations on DDT use for public health purposes have caused unnecessary morbidity and mortality from vector-borne diseases, with some claims of malaria deaths ranging as high as the hundreds of thousands and millions. Robert Gwadz of the US National Institutes of Health said in 2007, "The ban on DDT may have killed 20 million children." These arguments were rejected as "outrageous" by former WHO scientist Socrates Litsios. May Berenbaum, University of Illinois entomologist, says, "to blame environmentalists who oppose DDT for more deaths than Hitler is worse than irresponsible". More recently, Dr. Michael Palmer, a professor of chemistry at the University of Waterloo, has pointed out that DDT is still used to prevent malaria, that its declining use is primarily due to increases in manufacturing costs, and that in Africa, efforts to control malaria have been regional or local, not comprehensive.
Criticisms of a DDT "ban" often specifically reference the 1972 United States ban (with the erroneous implication that this constituted a worldwide ban and prohibited use of DDT in vector control). Reference is often made to Silent Spring, even though Carson never pushed for a DDT ban. John Quiggin and Tim Lambert wrote, "the most striking feature of the claim against Carson is the ease with which it can be refuted".
Organophosphate and carbamate insecticides, e.g. malathion and bendiocarb, respectively, are more expensive than DDT per kilogram and are applied at roughly the same dosage. Pyrethroids such as deltamethrin are also more expensive than DDT, but are applied more sparingly (0.02–0.3 g/m2 vs 1–2 g/m2), so the net cost per house per treatment is about the same. It must be noted that DDT has one of the longest resiudal efficacy periods of any IRS insecticide, lasting 6 to 12 months. Pyrethroids will remain active for only 4 to 6 months, and organophosphates and carbamates remain active for 2 to 6 months. In many malaria-endemic countries, malaria transmission occurs year-round, meaning that the high expense conducting a spray campaign (including hiring spray operators, procuring insecticides, and conducting pre-spray outreach campaings to encourage people to be home and to accept the intervention) will need to occur multiple times per year for these shorter lasting insecticides.
Before DDT, malaria was successfully eliminated or curtailed in several tropical areas by removing or poisoning mosquito breeding grounds and larva habitats, for example by eliminating standing water. These methods have seen little application in Africa for more than half a century. According to CDC, such methods are not practical in Africa because "Anopheles gambiae, one of the primary vectors of malaria in Africa, breeds in numerous small pools of water that form due to rainfall ... It is difficult, if not impossible, to predict when and where the breeding sites will form, and to find and treat them before the adults emerge."
The relative effectiveness of IRS versus other malaria control techniques (e.g. bednets or prompt access to anti-malarial drugs) varies and is dependent on local conditions.
A WHO study released in January 2008 found that mass distribution of insecticide-treated mosquito nets and artemisinin–based drugs cut malaria deaths in half in malaria-burdened Rwanda and Ethiopia. IRS with DDT did not play an important role in mortality reduction in these countries.
Vietnam has enjoyed declining malaria cases and a 97% mortality reduction after switching in 1991 from a poorly funded DDT-based campaign to a program based on prompt treatment, bednets and pyrethroid group insecticides.
In Mexico, effective and affordable chemical and non-chemical strategies were so successful that the Mexican DDT manufacturing plant ceased production due to lack of demand.
A review of fourteen studies in sub-Saharan Africa, covering insecticide-treated nets, residual spraying, chemoprophylaxis for children, chemoprophylaxis or intermittent treatment for pregnant women, a hypothetical vaccine and changing front–line drug treatment, found decision making limited by the lack of information on the costs and effects of many interventions, the small number of cost-effectiveness analyses, the lack of evidence on the costs and effects of packages of measures and the problems in generalizing or comparing studies that relate to specific settings and use different methodologies and outcome measures. The two cost-effectiveness estimates of DDT residual spraying examined were not found to provide an accurate estimate of the cost-effectiveness of DDT spraying; the resulting estimates may not be good predictors of cost-effectiveness in current programs.
However, a study in Thailand found the cost per malaria case prevented of DDT spraying (US$1.87) to be 21% greater than the cost per case prevented of lambda-cyhalothrin–treated nets (US$1.54), casting some doubt on the assumption that DDT was the most cost-effective measure. The director of Mexico's malaria control program found similar results, declaring that it was 25% cheaper for Mexico to spray a house with synthetic pyrethroids than with DDT. However, another study in South Africa found generally lower costs for DDT spraying than for impregnated nets.
A more comprehensive approach to measuring cost-effectiveness or efficacy of malarial control would not only measure the cost in dollars, as well as the number of people saved, but would also consider ecological damage and negative human health impacts. One preliminary study found that it is likely that the detriment to human health approaches or exceeds the beneficial reductions in malarial cases, except perhaps in epidemics. It is similar to the earlier study regarding estimated theoretical infant mortality caused by DDT and subject to the criticism also mentioned earlier.
A comparison of four successful programs against malaria in Brazil, India, Eritrea and Vietnam does not endorse any single strategy but instead states, "Common success factors included conducive country conditions, a targeted technical approach using a package of effective tools, data-driven decision-making, active leadership at all levels of government, involvement of communities, decentralized implementation and control of finances, skilled technical and managerial capacity at national and sub-national levels, hands-on technical and programmatic support from partner agencies, and sufficient and flexible financing."
DDT resistant mosquitoes may be susceptible to pyrethroids in some countries. However, pyrethroid resistance in Anopheles mosquitoes is on the rise with resistant mosquitoes found in multiple countries.
In general, incidental human exposure to DDT has been considered relatively non-toxic, but prolonged exposure has long been recognized to adversely affect reproduction.
Overall, the few studies conducted to date suggest that DDT exposure may affect time to pregnancy, but more research is needed.
In professional wrestling a DDT is any move in which the wrestler has the opponent in a front facelock/inverted headlock, and falls down or backwards to drive the opponent's head into the mat. The classic DDT is performed by putting the opponent in a front facelock and falling backwards so that the opponent is forced to dive forward onto his or her head. Although widely credited as an invention of Jake Roberts, who gave the DDT its famous name, the earliest known practitioner of the move was Mexican wrestler Black Gordman, who frequently performed it during the 1970s.Rumors abound as to what the letters DDT supposedly stood for, including Damien's Death Trap, Damien's Death Touch, Damien's Dinner Time (all named after Jake's pet python, Damien), Drape Drop Takedown Drop Down Town and Death Drop Technique. When asked what DDT meant, Jake once famously replied "The End." The abbreviation itself originally came from the chemical dichlorodiphenyltrichloroethane, a notorious pesticide, as stated during shoot interviews and Jake's Pick Your Poison DVD.DDT Pro-Wrestling
DDT Pro-Wrestling (DDTプロレスリング, DDT Puroresuringu) is a Japanese professional wrestling promotion based in Shinjuku, Tokyo, Japan. Its name stands for Dramatic Dream Team, which was the promotion's official name from 1997 to 2004. Founded in March 1997 by Shintaro Muto, but the promotion was eventually bought and managed by Shoichi Ichimiya until December 2005, when Sanshiro Takagi took over as the new president. In 2017, DDT was sold to CyberAgent. Takagi retained his position, while Takahiro Yamauchi took over as the new DDT director.
DDT became one of the top promotions in Japanese indie wrestling by creating a unique sports entertainment style, often parodying WWE, with a Japanese puroresu flair to the matches. DDT has had agreements with various MMA and professional wrestling promotions around the world. DDT's biggest event is the Ryōgoku Peter Pan, held each year since 2009.Daisuke Sasaki
Daisuke Sasaki (佐々木 大輔, Sasaki Daisuke, born November 22, 1985) is a Japanese professional wrestler signed to the DDT Pro-Wrestling promotion, where he is a former one-time KO-D Openweight Champion, one-time DDT Extreme Division Champion, four-time KO-D Tag Team Champion, three-time KO-D 6-Man Tag Team Champion and a three-time Ironman Heavymetalweight Champion. Sasaki has also made several appearances for New Japan Pro-Wrestling, working in the promotion's junior heavyweight division.Dichlorodiphenyldichloroethylene
Dichlorodiphenyldichloroethylene (DDE) is a chemical compound formed by the loss of hydrogen chloride (dehydrohalogenation) from DDT, of which it is one of the more common breakdown products. Due to DDT’s massive prevalence in society and agriculture during the mid 20th century, DDT and DDE are still widely seen in animal tissue samples. DDE is particularly dangerous because it is fat-soluble like other organochlorines; thus, it is rarely excreted from the body, and concentrations tend to increase throughout life. The major exception is the excretion of DDE in breast milk, which transfers a substantial portion of the mother's DDE burden to the young animal or child. Along with accumulation over an organism's lifetime, this stability leads to bioaccumulation in the environment, which amplifies DDE’s negative effects.Dicofol
Dicofol is an organochlorine pesticide that is chemically related to DDT. Dicofol is a miticide that is very effective against spider mite.
One of the intermediates used in its production is DDT. This has caused criticism by many environmentalists; however, the World Health Organization classifies dicofol as a Level II, "moderately hazardous" pesticide. It is known to be harmful to aquatic animals, and can cause eggshell thinning in various species of birds.Insecticide
Insecticides are substances used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to be a major factor behind the increase in the 20th-century's agricultural productivity. Nearly all insecticides have the potential to significantly alter ecosystems; many are toxic to humans and/or animals; some become concentrated as they spread along the food chain.
Insecticides can be classified into two major groups: systemic insecticides, which have residual or long term activity; and contact insecticides, which have no residual activity.
Furthermore, one can distinguish three types of insecticide. 1. Natural insecticides, such as nicotine, pyrethrum and neem extracts, made by plants as defenses against insects. 2. Inorganic insecticides, which are metals. 3. Organic insecticides, which are organic chemical compounds, mostly working by contact.
The mode of action describes how the pesticide kills or inactivates a pest. It provides another way of classifying insecticides. Mode of action is important in understanding whether an insecticide will be toxic to unrelated species, such as fish, birds and mammals.
Insecticides may be repellent or non-repellent. Social insects such as ants cannot detect non-repellents and readily crawl through them. As they return to the nest they take insecticide with them and transfer it to their nestmates. Over time, this eliminates all of the ants including the queen. This is slower than some other methods, but usually completely eradicates the ant colony.Insecticides are distinct from non-insecticidal repellents, which repel but do not kill.Keisuke Ishii
Keisuke Ishii (石井慧介, Ishii Keisuke, born February 6, 1985) is a Japanese professional wrestler trained by and signed to Dramatic Dream Team (DDT). Ishii also competes for All Japan Pro Wrestling (AJPW), where he is a former World Junior Heavyweight Champion.Kenny Omega
Tyson Smith (born October 16, 1983) is a Canadian-born Japanese professional wrestler better known by the ring name Kenny Omega. He is an executive vice president of All Elite Wrestling, where he also serves as an in-ring talent.
Omega is known for his tenure in New Japan Pro-Wrestling, where he was a one-time IWGP Heavyweight Champion, one-time and inaugural IWGP United States Champion, and one-time IWGP Intercontinental Champion among other championships. He was a member of the stable Bullet Club, later serving as its fourth leader. He became the first and only non-Japanese professional wrestler to win the G1 Climax, the promotion's premier tournament, when he defeated Hirooki Goto in the 2016 finals. Omega has also performed as part of both American and Japanese independent promotions, such as DDT Pro-Wrestling, Jersey All Pro Wrestling, Ring of Honor, and Pro Wrestling Guerrilla.
In 2017, Omega was named Sports Illustrated's Wrestler of the Year. The following year, he topped Pro Wrestling Illustrated's list of top 500 male wrestlers. He has also attained the publication's Match of the Year distinction twice. One of those matches, in which Omega battled Kazuchika Okada in a two out of three falls match at Dominion 6.9 in Osaka-jo Hall in June 2018, received a seven-star rating from combat sports journalist Dave Meltzer, the highest of any rating ever given to a professional wrestling match by Meltzer.Konosuke Takeshita
Konosuke Takeshita (竹下 幸之介, Takeshita Kōnosuke, born May 29, 1995) is a Japanese professional wrestler, who has worked for DDT Pro-Wrestling (DDT) since his debut in August 2012. Dubbed the "Future of DDT", Takeshita was named the Rookie of the Year by Tokyo Sports in 2013. He is the youngest KO-D Openweight Champion in history, having won the title on his 21st birthday, and has also held the KO-D Tag Team Championship, the KO-D 6-Man Tag Team Championship and the Ironman Heavymetalweight Championship.Kota Ibushi
Kota Ibushi (飯伏幸太, Ibushi Kōta, born May 21, 1982) is a Japanese martial artist and professional wrestler currently under full time contract with New Japan Pro-Wrestling. He previously worked as Tiger Mask W, the protagonist of the anime of the same name. He has also used ring names such as Hustle Kamen Orange, Oda Nobunaga, Robin Mask, and Sammy Lee Jr.. Ibushi teamed up with Kenny Omega for a number of years under the name the "Golden☆Lovers", working for several promotions and winning several tag team championships before breaking up. He later saved Omega from an attack by Bullet Club, leading to the two, and The Young Bucks (Matt and Nick Jackson) forming a group called "The Golden☆Elite".
His career began with the Dramatic Dream Team (DDT) promotion in 2004 and over the next eleven years became a three-time KO-D Openweight Champion, five-time KO-D Tag Team Champion and a two-time KO-D 6-Man Tag Team Champion. In 2009, Ibushi started working for New Japan Pro-Wrestling (NJPW) and eventually signed with the promotion in 2013. In NJPW, Ibushi is a former NEVER Openweight Champion, three-time IWGP Junior Heavyweight Champion and a one-time IWGP Junior Heavyweight Tag Team Champion. He resigned from both DDT and NJPW in February 2016 and has since been performing in several different organizations as a freelancer, including both DDT and NJPW as well as WWE, where he participated in the 2016 Cruiserweight Classic tournament. In early 2019, he signed a full-time contract with NJPW, and later won the IWGP Intercontinental Championship.Kudo (wrestler)
Atsushi Kudo (工藤 敦, Kudō Atsushi) is a Japanese professional wrestler, better known by the ring name Kudo (stylized in all capital letters). Signed to the DDT Pro-Wrestling promotion, he is currently in his seventh reign as one third of the KO-D 6-Man Tag Team Champions, while also being a former four-time KO-D Openweight Champion, four-time KO-D Tag Team Champion and the winner of the 2005 and 2011 King of DDT tournaments. Kudo has also made several trips to the United States, working for various independent promotions including Chikara, Independent Wrestling Association Mid-South (IWA-MS), International Wrestling Cartel (IWC), IWA East Coast and NWA Upstate.Masa Takanashi
Masahiro Takanashi (高梨 将弘, Takanashi Masahiro, born January 22, 1983) is a Japanese professional wrestler, better known by the ring name Masa Takanashi (マサ 高梨, Masa Takanashi). Takanashi was trained by Dramatic Dream Team (DDT) and has worked for the promotion since his debut in September 2003, becoming a one-time KO-D Openweight Champion, a two-time KO-D Tag Team Champion, a seven-time KO-D 6-Man Tag Team Champion, a two-time DDT Extreme Division Champion, an 18-time Ironman Heavymetalweight Champion and a one-time UWA World Trios Champion. Takanashi is also known for his work in women's wrestling promotion Ice Ribbon, where he performed under the ring name Ribbon Takanashi (リボン高梨, Ribon Takanashi) and became a one-time International Ribbon Tag Team and Triangle Ribbon Champion.Masato Shibata
Masato Shibata (柴田 正人, Shibata Masato, born September 13, 1978) is a Japanese professional wrestler primarily working for DDT, where he competes as part of the Damnation unit under the ring name Mad Paulie (マッド・ポーリー, Maddo Pōrī).Methoxychlor
Methoxychlor is a synthetic organochloride insecticide, now obsolete.Mickey Slim
The Mickey Slim was a drink that had short-lived popularity in the United States in the 1940s and 1950s. According to The Dedalus Book of Absinthe by Phil Baker, it was made by combining gin with a pinch of DDT (dichlorodiphenyltrichloroethane), an insecticide that would later be banned in most countries; consumers of this concoction claimed that its effects were similar to absinthe.
Due to lack of documentary evidence, it has been questioned whether this is a modern urban legend.Time Magazine, August 1, 1971 reported that Pest Control Executive Robert Loibl and his wife Louise start breakfast with a 10 mg capsule of DDT to demonstrate its safety, doing so for three months in front of witnesses. A famous British entomologist, Kenneth Mellanby, often ate small amounts of DDT during his 40 years of lectures. Professor Gordon Edwards also demonstrated this frequently, and he appeared in the September 1971 edition of Esquire magazine doing so. None of them reported any psychoactive effects of their consumption of DDT.
There have been no reports of this tasteless chemical having any psychoactive effects, thus it is unlikely that it has an effect "similar to absinthe", especially since the assumed psychedelic effect of absinthe, that is, the effect of the chemical thujone, has in recent times been revealed to be close to non-existent.This beverage should not be confused with the knockout drink known as the Mickey Finn.Paul Hermann Müller
Paul Hermann Müller also known as Pauly Mueller (12 January 1899 – 13 October 1965) was a Swiss chemist who received the 1948 Nobel prize in Physiology or Medicine for his 1939 discovery of insecticidal qualities and use of DDT in the control of vector diseases such as malaria and yellow fever.Professional wrestling aerial techniques
Aerial techniques, also known as "High-flying moves" are maneuvers in professional wrestling using the ring's posts and ropes as aids, in many cases to demonstrate the speed and agility of smaller, nimble and acrobatically inclined wrestlers preferring this style instead of throwing or locking the opponent. Due to injuries caused by these high risk moves, some promotions have banned the use of some of them. The next list of maneuvers was made under general categories whenever possible.Shigehiro Irie
Shigehiro Irie (入江 茂弘, Irie Shigehiro, born March 28, 1988) is a Japanese professional wrestler and former mixed martial artist best known for his work in DDT Pro-Wrestling (DDT). Irie has also competed for All Japan Pro Wrestling (AJPW), Big Japan Pro Wrestling (BJW), and a number of North American independent promotions in the past.Silent Spring
Silent Spring is an environmental science book by Rachel Carson. The book was published on September 27, 1962, documenting the adverse environmental effects caused by the indiscriminate use of pesticides. Carson accused the chemical industry of spreading disinformation, and public officials of accepting the industry's marketing claims unquestioningly.
Starting in the late 1950s, prior to the book's publication, Carson had focused her attention on environmental conservation, especially environmental problems that she believed were caused by synthetic pesticides. The result of her research was Silent Spring, which brought environmental concerns to the American public. The book was met with fierce opposition by chemical companies, but, owing to public opinion, it brought about numerous changes. It spurred a reversal in the United States' national pesticide policy, led to a nationwide ban on DDT for agricultural uses, and helped to inspire an environmental movement that led to the creation of the U.S. Environmental Protection Agency.Over three decades later, in 1996, a follow-up book, Beyond Silent Spring, co-written by H.F. van Emden and David Peakall, was published. In 2006, Silent Spring was named one of the 25 greatest science books of all time by the editors of Discover magazine.
|Insect growth regulators|
Cancer-causing materials and agents (carcinogens)
|Prominent human carcinogens|
|Adulterants, food contaminants|
|Parasitic infections through food|
|Toxins, poisons, environment pollution|
|Food contamination incidents|
|Regulation, standards, watchdogs|