# Cleon I

Cleon I is a character in the fictional universe of Isaac Asimov's Foundation Series. He was the last Emperor of the Entun dynasty (11,988 GE – 12,038 GE in the timeline of the novels). He was Emperor of the Galactic Empire when Hari Seldon first arrived on Trantor. He succeeded to the Imperial throne in 12,010 GE at the age of twenty-two following the death of his father, Stanel VI, who was fortunate enough to escape the roughly one-in-two chances of assassination faced by the last century of Galactic Emperors.

Asimov portrays Cleon as an amiable man, no longer enthusiastic about the trappings of office, eager to treat others as his equals and yet not capable of conversing comfortably—or even understanding their motivations. In his genial but misguided well-wishing, he is similar to the portrayal of Austrian emperor Joseph II in Amadeus (a film which Asimov admired), although he is not very similar to the historical Joseph II.

## Meeting with Seldon

Arguably, the most significant event of Cleon's rule occurred in 12,020 GE, when the young mathematician Hari Seldon came to Trantor and revealed that psychohistory was a theoretical possibility. Cleon I’s reign represented a curious interval of quiet between troubled times. This is undoubtedly due to the skills of his Chief of Staff, Eto Demerzel. Cleon would never have learned of this development by his own efforts; insulated from the Galaxy and confined to the Imperial Palace's grounds, he relied upon Demerzel to conduct the Machiavellian maneuvers required to keep the Empire functioning. Demerzel became aware that Seldon could possibly develop a mathematical method for predicting future history, and he (indirectly) informed the Emperor, who took an immediate interest in the matter. While Cleon was content to use Seldon as a source of self-fulfilling prophecies—a tool to prevent unrest—Demerzel had come to believe that the Empire itself was dying, and that only an honest investigation could prevent its fall or at least minimize that fall's effects. Therefore, Demerzel took steps to promote Seldon's development of his infant science.

## First Ministry of Seldon

After Demerzel's retirement, Cleon appointed Seldon to be his new Chief of Staff, a position now termed First Minister. (Prelude to Foundation states that Demerzel had no formal title, while its sequel, Forward the Foundation, makes him the First Minister) Seldon exerted himself to the fullest, employing pragmatic measures to halt anti-Imperial conspiracies while simultaneously developing psychohistory into a system capable of making solid predictions.

## Assassination

Cleon's personal ineptitude became his downfall. Wishing to thank a gardener, Mandel Gruber, for his part in thwarting an assassination attempt on Dr. Seldon, he promoted Gruber to Chief Gardener over the Imperial Palace grounds. Gruber, not wishing to abandon his lifestyle of being out in the open for the Head Gardener's administrative role, had a mental breakdown and shot the Emperor. The chaotic upset which followed Cleon's assassination saw the rise of a military junta and Hari Seldon's retirement from overt politics.

Beta-ketoacyl-(acyl-carrier-protein) synthase III

In enzymology, a β-ketoacyl-[acyl-carrier-protein] synthase III (EC 2.3.1.180) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + malonyl-[acyl carrier protein] ${\displaystyle \rightleftharpoons }$ acetoacetyl-[acyl carrier protein] + CoA + CO2

Thus, the two substrates of this enzyme are acetyl-CoA and malonyl-[acyl-carrier-protein], whereas its 3 products are acetoacetyl-[acyl-carrier-protein], CoA, and CO2. This enzyme belongs to the family of transferases, to be specific those acyltransferases transferring groups other than aminoacyl groups.

This enzyme participates in fatty acid biosynthesis. β-Ketoacyl-acyl-carrier-protein synthase III is involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The role of FabH in fatty acid synthesis has been described in Streptomyces glaucescens, Streptococcus pneumoniae, and Streptomyces coelicolor.

Forward the Foundation

Forward the Foundation is a novel by American writer Isaac Asimov, published posthumously in 1993. It is the second of two prequels to the Foundation Series. It is written in much the same style as the original novel Foundation, a novel composed of chapters with long intervals in between. Both books were first published as independent short stories in science fiction magazines.

The parallels between Hari Seldon and Isaac Asimov found in this book— the last one written by Asimov before his death— and the focus on Hari Seldon as he grows old and dies, strengthen the idea that Asimov considered Seldon his literary alter ego. Critics such as Josh Wimmer and Alasdair Wilkins have regarded many of the opinions and viewpoints expressed by Seldon in this book as autobiographical. Thus, a detailed reading of Forward the Foundation can shed light on Asimov's inner thoughts at the end of his life.Like other previous science fiction works by Asimov, the book was a commercial success, becoming a New York Times bestselling work.

Foundation's Fear

Foundation's Fear (1997) is a science fiction novel by American writer Gregory Benford, set in Isaac Asimov's Foundation universe. It is the first book of the Second Foundation trilogy, which was written after Asimov's death by three authors, authorized by the Asimov estate.

Foundation series

The Foundation series is a science fiction book series written by American author Isaac Asimov. For nearly thirty years, the series was a trilogy: Foundation, Foundation and Empire, and Second Foundation. It won the one-time Hugo Award for "Best All-Time Series" in 1966. Asimov began adding to the series in 1981, with two sequels: Foundation's Edge, Foundation and Earth, and two prequels: Prelude to Foundation, Forward the Foundation. The additions made reference to events in Asimov's Robot and Empire series, indicating that they were also set in the same fictional universe.

The premise of the series is that the mathematician Hari Seldon spent his life developing a branch of mathematics known as psychohistory, a concept of mathematical sociology. Using the laws of mass action, it can predict the future, but only on a large scale. Seldon foresees the imminent fall of the Galactic Empire, which encompasses the entire Milky Way, and a dark age lasting 30,000 years before a second great empire arises. Seldon's calculations also show there is a way to limit this interregnum to just one thousand years. To ensure the more favorable outcome and reduce human misery during the intervening period, Seldon creates the Foundation – a group of talented artisans and engineers positioned at the twinned extreme ends of the galaxy – to preserve and expand on humanity's collective knowledge, and thus become the foundation for the accelerated resurgence of this new galactic empire.

Galactic Empire (Isaac Asimov)

The Galactic Empire is an interstellar empire featured in Isaac Asimov's Robot, Galactic Empire, and Foundation series. The Empire is spread across the Milky Way galaxy and consists of almost 25 million planets settled exclusively by humans. It had a total population of 500 quintillion. For over 12 millennia the seat of imperial authority was located on the ecumenopolis of Trantor, whose population exceeded 40 billion, until it was sacked in the year 12,328. The official symbol of the empire is the Spaceship-and-Sun. Cleon II was the last Emperor to hold significant authority. The fall of the empire, modelled on the fall of the Roman Empire, is the subject of many of Asimov's novels.

Hari Seldon

Hari Seldon is a fictional character in Isaac Asimov's Foundation series. In his capacity as mathematics professor at Streeling University on the planet Trantor, Seldon develops psychohistory, an algorithmic science that allows him to predict the future in probabilistic terms. On the basis of his psychohistory he is able to predict the eventual fall of the Galactic Empire and to develop a means to shorten the millennia of chaos to follow. The significance of his discoveries lies behind his nickname "Raven" Seldon.

In the first five books of the Foundation series, Hari Seldon made only one in-the-flesh appearance, in the first part of the first book (Foundation), although he did appear at other times in pre-recorded messages to reveal a Seldon Crisis. After writing five books in chronological order, Asimov went back with two books to better describe the initial process. The two prequels—Prelude to Foundation and Forward the Foundation—describe his life in considerable detail. He is also the central character of the Second Foundation Trilogy written after Asimov's death (Foundation's Fear by Gregory Benford, Foundation and Chaos by Greg Bear, and Foundation's Triumph by David Brin), which are set after Asimov's two prequels.

Hemoglobin, alpha 2

Hemoglobin, alpha 2 also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin.

List of Foundation series characters

This is a list of characters in Isaac Asimov's Foundation series.

Mollusc shell

The mollusc (or mollusk) shell is typically a calcareous exoskeleton which encloses, supports and protects the soft parts of an animal in the phylum Mollusca, which includes snails, clams, tusk shells, and several other classes. Not all shelled molluscs live in the sea; many live on the land and in freshwater.

The ancestral mollusc is thought to have had a shell, but this has subsequently been lost or reduced on some families, such as the squid, octopus, and some smaller groups such as the caudofoveata and solenogastres, and the highly derived Xenoturbella. Today, over 100,000 living species bear a shell; there is some dispute as to whether these shell-bearing molluscs form a monophyletic group (conchifera) or whether shell-less molluscs are interleaved into their family tree.Malacology, the scientific study of molluscs as living organisms, has a branch devoted to the study of shells, and this is called conchology—although these terms used to be, and to a minor extent still are, used interchangeably, even by scientists (this is more common in Europe).

Within some species of molluscs, there is often a wide degree of variation in the exact shape, pattern, ornamentation, and color of the shell.

Prelude to Foundation

Prelude to Foundation is a novel by American writer Isaac Asimov, published in 1988. It is one of two prequels to the Foundation series. For the first time, Asimov chronicles the fictional life of Hari Seldon, the man who invented psychohistory and the intellectual hero of the series. The novel was nominated for the Locus Award.

R. Daneel Olivaw

R. Daneel Olivaw is a fictional robot created by Isaac Asimov. The "R" initial in his name stands for "Robot," a naming convention in Asimov's future society. Daneel appears in Asimov's Robot and Foundation series, most notably in the novels The Caves of Steel, The Naked Sun, The Robots of Dawn, Robots and Empire, Prelude to Foundation, Forward the Foundation, Foundation and Earth as well as the short story "Mirror Image". He is constructed immediately prior to the age of the Settlers, and lives at least until the formation of Galaxia, thus spanning the entire history of the First Empire, the Second Empire run by the Second Foundation, and finally the group consciousnesses of Galaxia, although this last is uncertain as no book about this was ever written.

Trantor

Trantor is a fictional planet in Isaac Asimov's Foundation Series and Empire series of science fiction novels.

Trantor was first mentioned in Asimov's short story, "Black Friar of the Flame", later collected in The Early Asimov, Volume 1. It was described as a human-settled planet in the part of the galaxy not ruled by an intelligent reptilian race (later defeated). Later, Trantor gained prominence when the 1940s Foundation series first appeared in print (in the form of short stories). Asimov described Trantor as being in the center of the galaxy. In later stories he acknowledged the growth in astronomical knowledge by retconning its position to be as close to the galactic center as was compatible with human habitability. The first time it was acknowledged in novel form was in Pebble in the Sky.

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