|1093 in various calendars|
|Ab urbe condita||1846|
|Balinese saka calendar||1014–1015|
|English Regnal year||6 Will. 2 – 7 Will. 2|
|Chinese calendar||壬申年 (Water Monkey)|
3789 or 3729
— to —
癸酉年 (Water Rooster)
3790 or 3730
|- Vikram Samvat||1149–1150|
|- Shaka Samvat||1014–1015|
|- Kali Yuga||4193–4194|
|Japanese calendar||Kanji 7|
|Minguo calendar||819 before ROC|
|Seleucid era||1404/1405 AG|
|Thai solar calendar||1635–1636|
1219 or 838 or 66
— to —
1220 or 839 or 67
BRENDA (The Comprehensive Enzyme Information System) is an information system representing one of the most comprehensive enzyme repositories. It is an electronic resource that comprises molecular and biochemical information on enzymes that have been classified by the IUBMB. Every classified enzyme is characterized with respect to its catalyzed biochemical reaction. Kinetic properties of the corresponding reactants (that is, substrates and products) are described in detail. BRENDA contains enzyme-specific data manually extracted from primary scientific literature and additional data derived from automatic information retrieval methods such as text mining. It provides a web-based user interface that allows a convenient and sophisticated access to the data.BacDive
BacDive (the Bacterial Diversity Metadatabase) is a bacterial metadatabase that provides strain-linked information about bacterial and archaeal biodiversity.DrugBank
The DrugBank database is a comprehensive, freely accessible, online database containing information on drugs and drug targets. As both a bioinformatics and a cheminformatics resource, DrugBank combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. DrugBank uses a fair bit of content from Wikipedia. Wikipedia also often links to Drugbank.
The latest release of the database (version 5.0) contains 9591 drug entries including 2037 FDA-approved small molecule drugs, 241 FDA-approved biotech (protein/peptide) drugs, 96 nutraceuticals and over 6000 experimental drugs. Additionally, 4270 non-redundant protein (i.e. drug target/enzyme/transporter/carrier) sequences are linked to these drug entries. Each DrugCard entry (Fig. 1) contains more than 200 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data.Four additional databases, HMDB, T3DB, SMPDB and FooDB are also part of a general suite of metabolomic/cheminformatic databases. HMDB contains equivalent information on more than 40,000 human metabolites, T3DB contains information on 3100 common toxins and environmental pollutants, SMPDB contains pathway diagrams for nearly 700 human metabolic pathways and disease pathways, while FooDB contains equivalent information on ~28,000 food components and food additives.Henry III of England
Henry III (1 October 1207 – 16 November 1272), also known as Henry of Winchester, was King of England, Lord of Ireland, and Duke of Aquitaine from 1216 until his death. The son of King John and Isabella of Angoulême, Henry assumed the throne when he was only nine in the middle of the First Barons' War. Cardinal Guala declared the war against the rebel barons to be a religious crusade and Henry's forces, led by William Marshal, defeated the rebels at the battles of Lincoln and Sandwich in 1217. Henry promised to abide by the Great Charter of 1225, which limited royal power and protected the rights of the major barons. His early rule was dominated first by Hubert de Burgh and then Peter des Roches, who re-established royal authority after the war. In 1230, the King attempted to reconquer the provinces of France that had once belonged to his father, but the invasion was a debacle. A revolt led by William Marshal's son, Richard, broke out in 1232, ending in a peace settlement negotiated by the Church.
Following the revolt, Henry ruled England personally, rather than governing through senior ministers. He travelled less than previous monarchs, investing heavily in a handful of his favourite palaces and castles. He married Eleanor of Provence, with whom he had five children. Henry was known for his piety, holding lavish religious ceremonies and giving generously to charities; the King was particularly devoted to the figure of Edward the Confessor, whom he adopted as his patron saint. He extracted huge sums of money from the Jews in England, ultimately crippling their ability to do business, and as attitudes towards the Jews hardened, he introduced the Statute of Jewry, attempting to segregate the community. In a fresh attempt to reclaim his family's lands in France, he invaded Poitou in 1242, leading to the disastrous Battle of Taillebourg. After this, Henry relied on diplomacy, cultivating an alliance with Frederick II, Holy Roman Emperor. Henry supported his brother Richard in his bid to become King of the Romans in 1256, but was unable to place his own son Edmund on the throne of Sicily, despite investing large amounts of money. He planned to go on crusade to the Levant, but was prevented from doing so by rebellions in Gascony.
By 1258, Henry's rule was increasingly unpopular, the result of the failure of his expensive foreign policies and the notoriety of his Poitevin half-brothers, the Lusignans, as well as the role of his local officials in collecting taxes and debts. A coalition of his barons, initially probably backed by Eleanor, seized power in a coup d'état and expelled the Poitevins from England, reforming the royal government through a process called the Provisions of Oxford. Henry and the baronial government enacted a peace with France in 1259, under which Henry gave up his rights to his other lands in France in return for King Louis IX recognising him as the rightful ruler of Gascony. The baronial regime collapsed but Henry was unable to reform a stable government and instability across England continued.
In 1263, one of the more radical barons, Simon de Montfort, seized power, resulting in the Second Barons' War. Henry persuaded Louis to support his cause and mobilised an army. The Battle of Lewes occurred in 1264, where Henry was defeated and taken prisoner. Henry's eldest son, Edward, escaped from captivity to defeat de Montfort at the Battle of Evesham the following year and freed his father. Henry initially enacted a harsh revenge on the remaining rebels, but was persuaded by the Church to mollify his policies through the Dictum of Kenilworth. Reconstruction was slow and Henry had to acquiesce to various measures, including further suppression of the Jews, to maintain baronial and popular support. Henry died in 1272, leaving Edward as his successor. He was buried in Westminster Abbey, which he had rebuilt in the second half of his reign, and was moved to his current tomb in 1290. Some miracles were declared after his death; however, he was not canonised.House of Plantagenet
The House of Plantagenet () was a royal house which originated from the lands of Anjou in France. The name Plantagenet is used by modern historians to identify four distinct royal houses: the Angevins, who were also counts of Anjou; the main body of the Plantagenets following the loss of Anjou; and the Plantagenets' two cadet branches, the houses of Lancaster and York. The family held the English throne from 1154, with the accession of Henry II, until 1485, when Richard III died in battle.
Under the Plantagenets, England was transformed – although this was only partly intentional. The Plantagenet kings were often forced to negotiate compromises such as Magna Carta. These constrained royal power in return for financial and military support. The king was no longer just the most powerful man in the nation, holding the prerogative of judgement, feudal tribute and warfare. He now had defined duties to the realm, underpinned by a sophisticated justice system. A distinct national identity was shaped by conflict with the French, Scots, Welsh and Irish, and the establishment of English as the primary language.
In the 15th century, the Plantagenets were defeated in the Hundred Years' War and beset with social, political and economic problems. Popular revolts were commonplace, triggered by the denial of numerous freedoms. English nobles raised private armies, engaged in private feuds and openly defied Henry VI.
The rivalry between the House of Plantagenet's two cadet branches of York and Lancaster brought about the Wars of the Roses, a decades-long fight for the English succession, culminating in the Battle of Bosworth Field in 1485, when the reign of the Plantagenets and the English Middle Ages both met their end with the death of King Richard III. Henry VII, of Lancastrian descent, became king of England; five months later, he married Elizabeth of York, thus ending the Wars of the Roses, and giving rise to the Tudor dynasty. The Tudors worked to centralise English royal power, which allowed them to avoid some of the problems that had plagued the last Plantagenet rulers. The resulting stability allowed for the English Renaissance, and the advent of early modern Britain.In vitro fertilisation
In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm outside the body, in vitro ("in glass"). The process involves monitoring and stimulating a woman's ovulatory process, removing an ovum or ova (egg or eggs) from the woman's ovaries and letting sperm fertilise them in a liquid in a laboratory. After the fertilised egg (zygote) undergoes embryo culture for 2–6 days, it is implanted in the same or another woman's uterus, with the intention of establishing a successful pregnancy.
IVF is a type of assisted reproductive technology used for infertility treatment and gestational surrogacy. A fertilised egg may be implanted into a surrogate's uterus, and the resulting child is genetically unrelated to the surrogate. Some countries banned or otherwise regulate the availability of IVF treatment, giving rise to fertility tourism. Restrictions on the availability of IVF include costs and age, in order for a woman to carry a healthy pregnancy to term. IVF is generally not used until less invasive or expensive options have failed or been determined unlikely to work.
In 1978 Louise Brown was the first child successfully born after her mother received IVF treatment. Brown was born as a result of natural-cycle IVF, where no stimulation was made. The procedure took place at Dr Kershaw's Cottage Hospital (now Dr Kershaw's Hospice) in Royton, Oldham, England. Robert G. Edwards was awarded the Nobel Prize in Physiology or Medicine in 2010. The physiologist co-developed the treatment together with Patrick Steptoe and embryologist Jean Purdy but the latter two were not eligible for consideration as they had died and the Nobel Prize is not awarded posthumously.
With egg donation and IVF, women who are past their reproductive years, have infertile male partners, have idiopathic female-fertility issues, or have reached menopause, can still become pregnant. Adriana Iliescu held the record as the oldest woman to give birth using IVF and donated egg, when she gave birth in 2004 at the age of 66, a record passed in 2006. After the IVF treatment, some couples get pregnant without any fertility treatments. In 2018 it was estimated that eight million children had been born worldwide using IVF and other assisted reproduction techniques.KEGG
KEGG (Kyoto Encyclopedia of Genes and Genomes) is a collection of databases dealing with genomes, biological pathways, diseases, drugs, and chemical substances. KEGG is utilized for bioinformatics research and education, including data analysis in genomics, metagenomics, metabolomics and other omics studies, modeling and simulation in systems biology, and translational research in drug development.List of regicides of Charles I
Following the trial of Charles I in January 1649, 59 commissioners (judges) signed his death warrant. They, along with several key associates and numerous court officials, were the subject of punishment following the restoration of the monarchy in 1660 with the coronation of Charles II. Charles I's trial and execution had followed the second English Civil War in which his supporters, Royalist "Cavaliers", were opposed by the Parliamentarian "Roundheads", led by Oliver Cromwell.
With the return of Charles II, Parliament passed the Indemnity and Oblivion Act (1660), which granted amnesty to those guilty of most crimes committed during the Civil War and the Interregnum. Of those who had been involved in the trial and execution, 104 were specifically excluded from reprieve, although 24 had already died, including Cromwell, John Bradshaw (the judge who was president of the court), and Henry Ireton (a general in the Parliamentary army and Cromwell's son-in-law). They were given a posthumous execution: their remains were exhumed, and they were hanged and beheaded, and their bodies cast into a pit below the gallows. Their heads were placed on spikes at the end of Westminster Hall. Several others were hanged, drawn and quartered, while 19 were imprisoned for life. Property was confiscated from many, and most were barred from holding public office or title again. Twenty-one of those under threat fled England, mostly settling in the Netherlands or Switzerland, although three settled in New England.
There is no agreed definition of who is included in the list of regicides. The Indemnity and Oblivion Act did not use the term either as a definition of the act, or as a label for those involved. "Regicide" has never been a specific crime in English law, and has never been defined in law. Historians have identified different groups of people as being suitable for the name, and some do not include the associates who also faced trial and punishment.
The list has been cited as an early blacklist: the state papers of Charles II  state "If any innocent soul be found in this black list, let him not be offended at me, but consider whether some mistaken principle or interest may not have misled him to vote."Lophotrochozoa
Lophotrochozoa (, "crest/wheel animals") is a clade of protostome animals within the Spiralia. The taxon was established as a monophyletic group based on molecular evidence.Malcolm III of Scotland
Malcolm III (Gaelic: Máel Coluim mac Donnchada; c. 26 March 1031 – 13 November 1093) was King of Scots from 1058 to 1093. He was later nicknamed "Canmore" ("ceann mòr", Gaelic for "Great Chief": "ceann" denotes "leader", "head" (of state) and "mòr" denotes "pre-eminent", "great", and "big"). Malcolm's long reign of 35 years preceded the beginning of the Scoto-Norman age. Henry I of England and Eustace III of Boulogne were his sons-in-law, making him the maternal grandfather of Empress Matilda, William Adelin and Matilda of Boulogne. All three of them were prominent in English politics during the 12th century.
Malcolm's kingdom did not extend over the full territory of modern Scotland: the north and west of Scotland remained under Scandinavian rule following the Norse invasions. Malcolm III fought a series of wars against the Kingdom of England, which may have had as its objective the conquest of the English earldom of Northumbria. These wars did not result in any significant advances southward. Malcolm's primary achievement was to continue a lineage that ruled Scotland for many years, although his role as founder of a dynasty has more to do with the propaganda of his youngest son David I and his descendants than with history.Malcolm's second wife, St. Margaret of Scotland, is Scotland's only royal saint. Malcolm himself had no reputation for piety; with the notable exception of Dunfermline Abbey in Fife he is not definitely associated with major religious establishments or ecclesiastical reforms.Master of the Rolls
The Keeper or Master of the Rolls and Records of the Chancery of England, known as the Master of the Rolls, is the second-most senior judge in England and Wales after the Lord Chief Justice, and serves as President of the Civil Division of the Court of Appeal and Head of Civil Justice. The position dates from at least 1286, although it is believed that the office probably existed earlier than that.The Master of the Rolls was initially a clerk responsible for keeping the "Rolls" or records of the Court of Chancery, and was known as the Keeper of the Rolls of Chancery. The Keeper was the most senior of the dozen Chancery clerks, and as such occasionally acted as keeper of the Great Seal of the Realm. The post evolved into a judicial one as the Court of Chancery did; the first reference to judicial duties dates from 1520. With the Judicature Act 1873, which merged the Court of Chancery with the other major courts, the Master of the Rolls joined the Chancery Division of the High Court and the Court of Appeal, but left the Chancery Division by the terms of the Judicature Act 1881. The Master of the Rolls had also been warden of the little-used Domus Conversorum for housing Jewish converts, which led to the house and chapel being used to store legal documents and later becoming the location of the Public Record Office. He retained his clerical functions as the nominal head of the Public Record Office until the Public Records Act 1958 transferred responsibility for it to the Lord Chancellor. One residual reminder of this role is the fact that the Master of the Rolls of the day continues to serve, ex officio, as President of the British Records Association. The Master of the Rolls was also previously responsible for registering solicitors, the officers of the Senior Courts.One of the most prominent people to hold the position was Thomas Cromwell, a highly influential figure during the reign of Henry VIII; more recently, Lord Denning held the position for 20 years, from 1962 to 1982, and made sweeping changes in the common law. On 3 October 2016, Sir Terence Etherton succeeded Lord Dyson as Master of the Rolls.PDBsum
PDBsum is a database that provides an overview of the contents of each 3D macromolecular structure deposited in the Protein Data Bank. The original version of the database was developed around 1995 by Roman Laskowski and collaborators at University College London. As of 2014, PDBsum is maintained by Laskowski and collaborators in the laboratory of Janet Thornton at the European Bioinformatics Institute (EBI).
Each structure in the PDBsum database includes an image of structure (main view, Bottom view and right view), molecular components contained in the complex(structure), enzyme reaction diagram if appropriate, Gene ontology functional assignments, a 1D sequence annotated by Pfam and InterPro domain assignments, description of bound molecules and graphic showing interactions between protein and secondary structure, schematic diagrams of protein–protein interactions, analysis of clefts contained within the structure and links to external databases. The RasMol and Jmol molecular graphics software are used to provide a 3D view of molecules and their interactions within PDBsum.Since the release of the 1000 Genomes Project in October 2012, all single amino acid variants identified by the project have been mapped to the corresponding protein sequences in the Protein Data Bank. These variants are also displayed within PDBsum, cross-referenced to the relevant UniProt identifier. PDBsum contains a number of protein structures which may be of interest in structure-based drug design. One branch of PDBsum, known as DrugPort, focuses on these models and is linked with the DrugBank drug target database.Pfam
Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models. The most recent version, Pfam 31.0, was released in March 2017 and contains 16,712 families.Phylogenetics
In biology, phylogenetics (Greek: φυλή, φῦλον – phylé, phylon = tribe, clan, race + γενετικός – genetikós = origin, source, birth) is the study of the evolutionary history and relationships among individuals or groups of organisms (e.g. species, or populations). These relationships are discovered through phylogenetic inference methods that evaluate observed heritable traits, such as DNA sequences or morphology under a model of evolution of these traits. The result of these analyses is a phylogeny (also known as a phylogenetic tree) – a diagrammatic hypothesis about the history of the evolutionary relationships of a group of organisms. The tips of a phylogenetic tree can be living organisms or fossils, and represent the "end", or the present, in an evolutionary lineage. Phylogenetic analyses have become central to understanding biodiversity, evolution, ecology, and genomes.
Taxonomy is the identification, naming and classification of organisms. It is usually richly informed by phylogenetics, but remains a methodologically and logically distinct discipline. The degree to which taxonomies depend on phylogenies (or classification depends on evolutionary development) differs depending on the school of taxonomy: phenetics ignores phylogeny altogether, trying to represent the similarity between organisms instead; cladistics (phylogenetic systematics) tries to reproduce phylogeny in its classification without loss of information; evolutionary taxonomy tries to find a compromise between them.Poet Laureate of the United Kingdom
The British Poet Laureate is an honorary position appointed by the monarch of the United Kingdom on the advice of the Prime Minister. The role does not entail any specific duties, but there is an expectation that the holder will write verse for significant national occasions. The origins of the laureateship date back to 1616 when a pension was provided to Ben Jonson, but the first official holder of the position was John Dryden, appointed in 1668 by Charles II. On the death of Alfred, Lord Tennyson, who held the post between November 1850 and October 1892, there was a break of four years as a mark of respect; Tennyson's laureate poems "Ode on the Death of the Duke of Wellington" and "The Charge of the Light Brigade" were particularly cherished by the Victorian public. Five poets, Thomas Gray, Samuel Rogers, Walter Scott, Philip Larkin and Seamus Heaney, turned down the laureateship. The holder of the position as of 2019 is Carol Ann Duffy, who was appointed in May 2009 on a fixed ten-year term.PubMed
PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintains the database as part of the Entrez system of information retrieval.From 1971 to 1997, MEDLINE online access to the MEDLARS Online computerized database primarily had been through institutional facilities, such as university libraries. PubMed, first released in January 1996, ushered in the era of private, free, home- and office-based MEDLINE searching. The PubMed system was offered free to the public starting in June 1997.Saint Margaret of Scotland
Saint Margaret of Scotland (Scots: Saunt Magret, c. 1045 – 16 November 1093), also known as Margaret of Wessex, was an English princess and a Scottish queen. Margaret was sometimes called "The Pearl of Scotland". Born in exile in the Kingdom of Hungary, she was the sister of Edgar Ætheling, the shortly reigned and uncrowned Anglo-Saxon King of England. Margaret and her family returned to the Kingdom of England in 1057, but fled to the Kingdom of Scotland following the Norman conquest of England in 1066. By the end of 1070, Margaret had married King Malcolm III of Scotland, becoming Queen of Scots.
She was a very pious Roman Catholic, and among many charitable works she established a ferry across the Firth of Forth in Scotland for pilgrims travelling to St Andrews in Fife, which gave the towns of South Queensferry and North Queensferry their names. Margaret was the mother of three kings of Scotland, or four, if Edmund of Scotland (who ruled with his uncle, Donald III, is counted), and of a queen consort of England. According to the Vita S. Margaritae (Scotorum) Reginae (Life of St. Margaret, Queen (of the Scots)), attributed to Turgot of Durham, she died at Edinburgh Castle in Edinburgh, Scotland in 1093, merely days after receiving the news of her husband's death in battle.
In 1250, Pope Innocent IV canonized her, and her remains were reinterred in a shrine in Dunfermline Abbey in Fife, Scotland. Her relics were dispersed after the Scottish Reformation and subsequently lost. Mary, Queen of Scots, at one time owned her head, which was subsequently preserved by Jesuits in the Scottish College, Douai, France, from where it was subsequently lost during the French Revolution.Sequence homology
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs).Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. Significant similarity is strong evidence that two sequences are related by evolutionary changes from a common ancestral sequence. Alignments of multiple sequences are used to indicate which regions of each sequence are homologous.Superfamily database
SUPERFAMILY is a database of structural and functional annotation for all proteins and genomes. It classifies amino acid sequences into known structural domains, especially into SCOP superfamilies. Domains are functional, structural, and evolutionary units that form proteins. Domains of common Ancestry are grouped into superfamilies. The domains and domain superfamilies are defined and described in SCOP. Superfamilies are groups of proteins which have structural evidence to support a common evolutionary ancestor but may not have detectable sequence homology.UniProt
UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.